Neurological complications caused by SARS-CoV-2

Z Pang, A Tang, Y He, J Fan, Q Yang… - Clinical Microbiology …, 2024 - journals.asm.org
SUMMARY SARS-CoV-2 can not only cause respiratory symptoms but also lead to
neurological complications. Research has shown that more than 30% of SARS-CoV-2 …

[HTML][HTML] Fibrin drives thromboinflammation and neuropathology in COVID-19

JK Ryu, Z Yan, M Montano, EG Sozmen, K Dixit… - Nature, 2024 - nature.com
Life-threatening thrombotic events and neurological symptoms are prevalent in COVID-19
and are persistent in patients with long COVID experiencing post-acute sequelae of SARS …

Long COVID as a disease of accelerated biological aging: An opportunity to translate geroscience interventions

A Shafqat, MC Masters, U Tripathi, T Tchkonia… - Ageing Research …, 2024 - Elsevier
It has been four years since long COVID—the protracted consequences that survivors of
COVID-19 face—was first described. Yet, this entity continues to devastate the quality of life …

SARS-CoV-2 S1 subunit produces a protracted priming of the neuroinflammatory, physiological, and behavioral responses to a remote immune challenge: A role for …

MG Frank, JB Ball, S Hopkins, T Kelley… - Brain, Behavior, and …, 2024 - Elsevier
Long COVID is a major public health consequence of COVID-19 and is characterized by
multiple neurological and neuropsychatric symptoms. SARS-CoV-2 antigens (eg, spike S1 …

Plasma proteomic evidence for increased β-amyloid pathology after SARS-CoV-2 infection

EP Duff, H Zetterberg, A Heslegrave, A Dehghan… - Nature Medicine, 2025 - nature.com
Previous studies have suggested that systemic viral infections may increase risks of
dementia. Whether this holds true for severe acute respiratory syndrome coronavirus 2 …

Artificial intelligence with mass spectrometry-based multimodal molecular profiling methods for advancing therapeutic discovery of infectious diseases

J Liu, C Bao, J Zhang, Z Han, H Fang, H Lu - Pharmacology & Therapeutics, 2024 - Elsevier
Infectious diseases, driven by a diverse array of pathogens, can swiftly undermine public
health systems. Accurate diagnosis and treatment of infectious diseases—centered around …

Alzheimer's Disease Risk Gene SORL1 Promotes Receptiveness of Human Microglia to Pro‐Inflammatory Stimuli

PL Ovesen, K Juul‐Madsen, NS Telugu, V Schmidt… - Glia, 2024 - Wiley Online Library
Sorting protein‐related receptor containing class A repeats (SORLA) is an intracellular
trafficking receptor encoded by the Alzheimer's disease (AD) gene SORL1 (sortilin‐related …

CNS disease associated with enhanced type I interferon signalling

YJ Crow - The Lancet Neurology, 2024 - thelancet.com
The ability to mount an interferon-mediated innate immune response is essential in
protection against neurotropic viruses, but antiviral type I interferons also have neurotoxic …

High throughput spatial immune map** reveals an innate immune scar in post-COVID-19 brains

M Schwabenland, D Hasavci, S Frase, K Wolf… - Acta …, 2024 - Springer
The underlying pathogenesis of neurological sequelae in post-COVID-19 patients remains
unclear. Here, we used multidimensional spatial immune phenoty** and machine …

The fate of neuronal synapse homeostasis in aging, infection, and inflammation

C Tacke, P Landgraf, DC Dieterich… - American Journal of …, 2024 - journals.physiology.org
Neuroplasticity is the brain's ability to reorganize and modify its neuronal connections in
response to environmental stimuli, experiences, learning, and disease processes. This …