Strategies for targeting senescent cells in human disease
Cellular senescence represents a distinct cell fate characterized by replicative arrest in
response to a host of extrinsic and intrinsic stresses. Senescence facilitates programming …
response to a host of extrinsic and intrinsic stresses. Senescence facilitates programming …
[HTML][HTML] Mechanisms of cellular senescence: cell cycle arrest and senescence associated secretory phenotype
R Kumari, P Jat - Frontiers in cell and developmental biology, 2021 - frontiersin.org
Cellular senescence is a stable cell cycle arrest that can be triggered in normal cells in
response to various intrinsic and extrinsic stimuli, as well as developmental signals …
response to various intrinsic and extrinsic stimuli, as well as developmental signals …
Virus-induced senescence is a driver and therapeutic target in COVID-19
Derailed cytokine and immune cell networks account for the organ damage and the clinical
severity of COVID-19 (refs.,,–). Here we show that SARS-CoV-2, like other viruses, evokes …
severity of COVID-19 (refs.,,–). Here we show that SARS-CoV-2, like other viruses, evokes …
Cellular senescence in ageing: from mechanisms to therapeutic opportunities
Cellular senescence, first described in vitro in 1961, has become a focus for biotech
companies that target it to ameliorate a variety of human conditions. Eminently characterized …
companies that target it to ameliorate a variety of human conditions. Eminently characterized …
Senescence and the SASP: many therapeutic avenues
J Birch, J Gil - Genes & development, 2020 - genesdev.cshlp.org
Cellular senescence is a stress response that elicits a permanent cell cycle arrest and
triggers profound phenotypic changes such as the production of a bioactive secretome …
triggers profound phenotypic changes such as the production of a bioactive secretome …
Guidelines for minimal information on cellular senescence experimentation in vivo
Cellular senescence is a cell fate triggered in response to stress and is characterized by
stable cell-cycle arrest and a hypersecretory state. It has diverse biological roles, ranging …
stable cell-cycle arrest and a hypersecretory state. It has diverse biological roles, ranging …
Injectable hydrogel with MSNs/microRNA-21-5p delivery enables both immunomodification and enhanced angiogenesis for myocardial infarction therapy in pigs
Y Li, X Chen, R **, L Chen, M Dang, H Cao… - Science …, 2021 - science.org
Current therapeutic strategies such as angiogenic therapy and anti-inflammatory therapy for
treating myocardial infarction have limited success. An effective approach may benefit from …
treating myocardial infarction have limited success. An effective approach may benefit from …
Oxylipin-PPARγ-initiated adipocyte senescence propagates secondary senescence in the bone marrow
The chronic use of glucocorticoids decreases bone mass and quality and increases bone-
marrow adiposity, but the underlying mechanisms remain unclear. Here, we show that bone …
marrow adiposity, but the underlying mechanisms remain unclear. Here, we show that bone …
Neutrophils induce paracrine telomere dysfunction and senescence in ROS‐dependent manner
Cellular senescence is characterized by an irreversible cell cycle arrest as well as a pro‐
inflammatory phenotype, thought to contribute to aging and age‐related diseases …
inflammatory phenotype, thought to contribute to aging and age‐related diseases …
The senescence-associated secretory phenotype and its physiological and pathological implications
Cellular senescence is a state of terminal growth arrest associated with the upregulation of
different cell cycle inhibitors, mainly p16 and p21, structural and metabolic alterations …
different cell cycle inhibitors, mainly p16 and p21, structural and metabolic alterations …