Tumour initiation and progression requires the metabolic reprogramming of cancer cells.
Cancer cells autonomously alter their flux through various metabolic pathways in order to …

The hypoxia pathway not only regulates the organism to adapt to the special environment,
such as short-term hypoxia in the plateau under normal physiological conditions, but also …

Currently, stem cell transplantations in cardiac repair are limited owing to disadvantages,
such as immunological rejection and poor cell viability. Although direct injection of …

In pathological cardiac hypertrophy, the heart is more dependent on glucose than fatty acids.
This shift in energy metabolism occurs due to several factors, including the oxygen deficit …

Hypoxia is a prominent feature of tumors. Hypoxia-inducible factor-1α (HIF-1α), a major
subunit of HIF-1, is overexpressed in hypoxic tumor tissues and activates the transcription of …

Tight barriers are crucial for animals. Insect respiratory cells establish barriers through their
extracellular matrices. These chitinous-matrices must be soft and flexible to provide …

Although once considered by biologists almost exclusively for their toxicity, reactive oxygen
(ROS) and nitrogen (RNS) species produced within normal cells under baseline …

Cancer is a profoundly dynamic, heterogeneous and aggressive systemic ailment, with a
coordinated evolution of various types of tumor niches. Hypoxia plays an indispensable role …

Stroke is the most devastating disease, causing paralysis and eventually death. Many
clinical and experimental trials have been done in search of a new safe and efficient …

Background: The comparative benefits and acceptability of HIF-PHIs for treating anemia
have not been well researched to date. We sought to compare the effectiveness of 6 HIF …