Blood and lymphatic vessels are lined by endothelial cells which constantly interact with
their luminal and abluminal extracellular environments. These interactions confer physical …

Pulmonary arterial hypertension (PAH) is characterized by remodeling of the extracellular
matrix (ECM) of the pulmonary arteries with increased collagen deposition, cross-linkage of …

Pulmonary arterial hypertension is a chronic, progressive disorder of the pulmonary
vasculature with associated pulmonary and cardiac remodeling. PAH was a uniformly fatal …

The normal pulmonary circulation is a low-pressure, high-compliance system. Pulmonary
arterial compliance decreases in the presence of pulmonary hypertension because of …

Pulmonary hypertension (PH) due to left heart disease (LHD) is the most common type of PH
and is defined as mean pulmonary artery systolic pressure of> 20 mm Hg and pulmonary …

Alveolarization is the process by which the alveoli, the principal gas exchange units of the
lung, are formed. Along with the maturation of the pulmonary vasculature, alveolarization is …

Significance: Pulmonary arterial hypertension (PAH) is a progressive disease of the lung
vasculature characterized by the proliferation of all vascular wall cell types, including …

Pulmonary arterial stiffness is an independent risk factor for mortality in pulmonary
hypertension (PH) and plays a critical role in PH pathophysiology. Our laboratory has …

Pulmonary arterial (PA) stiffness is associated with increased mortality in patients with
pulmonary hypertension (PH); however, the role of PA stiffening in the pathogenesis of PH …

Exposure to hypoxia increases pulmonary vascular resistance, leading to elevated
pulmonary arterial pressure and, potentially, right heart failure. Vascular remodeling is an …