Type VII secretion systems (T7SSs) have a key role in the secretion of effector proteins in
non-pathogenic mycobacteria and pathogenic mycobacteria such as Mycobacterium …

1. Introduction 2. Computational tools for studying M. tuberculosis β-carbonic anhydrases 3.
Molecular biology 4. β-CA1 is induced during environmental stress 5. β-CA2 is essential for …

Pathogenic mycobacteria cause chronic and acute diseases ranging from human
tuberculosis (TB) to nontubercular infections. Mycobacterium tuberculosis causes both acute …

Bacteria transport proteins to diverse intracellular or extracellular locations to ensure proper
function. Proteins are localized intracellularly to the cytoplasm or the periplasm or …

Mycobacterium tuberculosis, the cause of human tuberculosis, and Mycobacterium
marinum, a nontubercular pathogen with a broad host range, require the ESX-1 secretion …

Pathogenic mycobacteria use the ESX-1 secretion system to escape the macrophage
phagosome and survive infection. We demonstrated that the ESX-1 system is regulated by …

Pathogenic mycobacteria encounter multiple environments during macrophage infection.
Temporally, the bacteria are engulfed into the phagosome, lyse the phagosomal membrane …

Mycobacteria use specialized type VII secretion systems (T7SSs) to secrete proteins across
their diderm cell envelope. One of the T7SS subtypes, named ESX-1, is a major virulence …

Bacterial pathogens use protein secretion systems to transport virulence factors and
regulate gene expression. Among pathogenic mycobacteria, including Mycobacterium …

Mycobacterium kansasii is an important opportunistic pathogen of humans and has a close
phylogenetic relationship with Mycobacterium tuberculosis. Seven subtypes (I–VII) have …