Sticking and picking during tablet manufacture has received increasing interest recently, as
it causes tablet defects, downtime in manufacturing, and yield losses. The capricious nature …

Due to the high surface area, adjustable surface and pore structures, and excellent
biocompatibility, nano-and micro-sized silica have certainly attracted the attention of many …

Direct compression (DC) is the easiest and most cost-effective process for tablet
manufacturing, because it only involves blending and compression. However, active …

The sticking of active pharmaceutical ingredient (API) to the surfaces of compaction tooling,
frequently referred to as punch sticking, causes costly downtime or product failures in …

External lubrication of tooling with magnesium stearate (MgSt) is a common strategy to
eliminate punch sticking when compressing powders with a high sticking propensity, such …

The development of a high quality tablet of Celecoxib (CEL) is challenged by poor
dissolution, poor flowability, and high punch sticking propensity of CEL. In this work, we …

An l-proline cocrystal of celecoxib was identified based on a computational approach for
predicting crystal mechanical properties in order to significantly reduce the punch sticking …

Punch-sticking during tablet compression is a common problem for many active
pharmaceutical ingredients (APIs), which renders tablet formulation development …

This work aims to improve direct compaction properties of Citri Reticulatae Pericarpium
powder (CB) by liquid dispersion co-processing with hydrophilic or hydrophobic nano-silica …

Powder adhesion or sticking onto punches is one of the outstanding issues in
pharmaceutical tablet manufacturing. We show in this work that, at comparable particle …