Anti-EFG1 2′-OMethylRNA oligomer inhibits Candida albicans filamentation and attenuates the candidiasis in Galleria mellonella

D Araújo, D Mil-Homens, M Henriques… - Molecular Therapy-Nucleic …, 2022 - cell.com
EFG1 is a central transcriptional regulator of filamentation that is an important virulence
factor of Candida albicans. This study serves to assess in vivo the applicability of the anti …

Cationic lipid-based formulations for encapsulation and delivery of anti-EFG1 2′ OMethylRNA oligomer

D Araújo, R Gaspar, D Mil-Homens… - Medical …, 2022 - academic.oup.com
The effective protection and delivery of antisense oligomers to its site of action is a challenge
without an optimal strategy. Some of the most promising approaches encompass the …

Polyamide Microsized Particulate Polyplex Carriers for the 2′-OMethylRNA EFG1 Antisense Oligonucleotide

D Araújo, J Braz, NV Dencheva, I Carvalho… - ACS Applied Bio …, 2021 - ACS Publications
Anti-EFG1 2′-O MethylRNA is an antisense oligonucleotide (ASO) that has the ability to
recognize and block the EFG1 gene and to control Candida albicans filamentation …