Phage proteins target and co-opt host ribosomes immediately upon infection
Bacteriophages must seize control of the host gene expression machinery to replicate. To
bypass bacterial anti-phage defence systems, this host takeover occurs immediately upon …
bypass bacterial anti-phage defence systems, this host takeover occurs immediately upon …
The intricate organizational strategy of nucleus-forming phages
Nucleus-forming phages (chimalliviruses) encode numerous genes responsible for creating
intricate structures for viral replication. Research on this newly appreciated family of phages …
intricate structures for viral replication. Research on this newly appreciated family of phages …
Nucleus-forming vibriophage cocktail reduces shrimp mortality in the presence of pathogenic bacteria
K Thammatinna, A Sinprasertporn, A Naknaen… - Scientific Reports, 2023 - nature.com
The global aquaculture industry has suffered significant losses due to the outbreak of Acute
Hepatopancreatic Necrosis Disease (AHPND) caused by Vibrio parahaemolyticus. Since …
Hepatopancreatic Necrosis Disease (AHPND) caused by Vibrio parahaemolyticus. Since …
A phage nucleus-associated RNA-binding protein is required for jumbo phage infection
Large-genome bacteriophages (jumbo phages) of the proposed family Chimalliviridae
assemble a nucleus-like compartment bounded by a protein shell that protects the …
assemble a nucleus-like compartment bounded by a protein shell that protects the …
An intron endonuclease facilitates interference competition between coinfecting viruses
Introns containing homing endonucleases are widespread in nature and have long been
assumed to be selfish elements that provide no benefit to the host organism. These genetic …
assumed to be selfish elements that provide no benefit to the host organism. These genetic …
[HTML][HTML] Sequential membrane-and protein-bound organelles compartmentalize genomes during phage infection
EG Armbruster, J Lee, J Hutchings, AR VanderWal… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Eukaryotic viruses assemble compartments required for genome replication, but no such
organelles are known to be essential for prokaryotic viruses. Bacteriophages of the family …
organelles are known to be essential for prokaryotic viruses. Bacteriophages of the family …
Genomic transfer via membrane vesicle: A strategy of giant phage phiKZ for early infection
D Antonova, A Nichiporenko, M Sobinina… - Journal of …, 2024 - journals.asm.org
During infection, the giant phiKZ phage forms a specialized structure at the center of the host
cell called the phage nucleus. This structure is crucial for safeguarding viral DNA against …
cell called the phage nucleus. This structure is crucial for safeguarding viral DNA against …
An essential and highly selective protein import pathway encoded by nucleus-forming phage
Targeting proteins to specific subcellular destinations is essential in prokaryotes,
eukaryotes, and the viruses that infect them. Chimalliviridae phages encapsulate their …
eukaryotes, and the viruses that infect them. Chimalliviridae phages encapsulate their …
Jumbo phages are active against extensively drug-resistant eyedrop-associated Pseudomonas aeruginosa infections
Antibiotic-resistant bacteria present an emerging challenge to human health. Their
prevalence has been increasing across the globe due in part to the liberal use of antibiotics …
prevalence has been increasing across the globe due in part to the liberal use of antibiotics …
Genome-wide characterization of diverse bacteriophages enabled by RNA-binding CRISPRi
Bacteriophages constitute one of the largest sources of unknown gene content in the
biosphere. Even for well-studied model phages, robust experimental approaches to identify …
biosphere. Even for well-studied model phages, robust experimental approaches to identify …