Abstract Sphingosine‐1‐phosphate (S1P) is a signalling lipid that regulates many cellular
processes in mammals. One well‐studied role of S1P signalling is to modulate T‐cell …

Sphingolipids are essential components of all eukaryotic membranes. The bioactive
sphingolipid molecule, Sphingosine 1-Phosphate (S1P), regulates various important …

Sepsis is a leading cause of death in critical illness, and its pathophysiology varies
depending on preexisting medical conditions. Here we identified nonalcoholic fatty liver …

Background Macrophages at infection sites are considered as the promising therapeutic
targets to prevent sepsis development. The Nrf2/Keap1 system acts as a critical modulator of …

The sphingolipid sphingosine-1-phosphate (S1P) is produced by sphingosine kinases to
either signal through intracellular targets or to activate a family of specific G-protein-coupled …

Sepsis is a leading cause of in‐hospital mortality resulting from a dysregulated response to
infection. Novel immunomodulatory therapies targeting macrophage metabolism have …

Sepsis is characterized as life-threatening organ dysfunction caused by a dysregulated host
response to an infection. Despite numerous clinical trials that addressed this syndrome …

Fingolimod is a well-tolerated, highly effective disease-modifying therapy successfully
utilized in the management of multiple sclerosis. The active metabolite, fingolimod …

The gut microbiome is recognized as a key modulator of sepsis development. However, the
contribution of the gut mycobiome to sepsis development is still not fully understood. Here …

Background Inhibition of sphingosine kinase 1 (SphK1), which catalyzes bioactive lipid
sphingosine-1–phosphate (S1P), attenuates NLRP3 inflammasome activation. S1P exerts …