Microglial research has advanced considerably in recent decades yet has been constrained
by a rolling series of dichotomies such as" resting versus activated" and" M1 versus M2." …

Tumour progression is modulated by the local microenvironment. This environment is
populated by many immune cells, of which macrophages are among the most abundant …

Macrophages are innate immune cells that form a 3D network in all our tissues, where they
phagocytose dying cells and cell debris, immune complexes, bacteria and other waste …

Tissue-resident alveolar and interstitial macrophages and recruited macrophages are critical
players in innate immunity and maintenance of lung homeostasis. Until recently, assessing …

Obesity leads to chronic, systemic inflammation and can lead to insulin resistance (IR), β-cell
dysfunction, and ultimately type 2 diabetes (T2D). This chronic inflammatory state …

Embryo-derived tissue-resident macrophages are the first representatives of the
haematopoietic lineage to emerge in metazoans. In mammals, resident macrophages …

Resident macrophages orchestrate homeostatic, inflammatory, and reparative activities. It is
appreciated that different tissues instruct specialized macrophage functions. However …

Macrophages have a key role in sha** the tumour microenvironment (TME), tumour
immunity and response to immunotherapy, which makes them an important target for cancer …

Mononuclear phagocytes (MNPs) encompass dendritic cells, monocytes, and macrophages
(MoMac), which exhibit antimicrobial, homeostatic, and immunoregulatory functions. We …

Microglia, the brain's resident macrophages, help to regulate brain function by removing
dying neurons, pruning non-functional synapses, and producing ligands that support …