Key molecular events in cervical cancer development
Cervical cancer is the fourth most common cancer among women. Infection by high-risk
human papillomavirus (HPV) is the main aetiology for the development of cervical cancer …
human papillomavirus (HPV) is the main aetiology for the development of cervical cancer …
Papillomavirus immune evasion strategies target the infected cell and the local immune system
Persistent infection with human papillomavirus (HPV) initiates~ 5% of all human cancers,
and particularly cervical and oropharyngeal cancers. HPV vaccines prevent HPV infection …
and particularly cervical and oropharyngeal cancers. HPV vaccines prevent HPV infection …
Regulatory T cells in cancer
D Mougiakakos, A Choudhury, A Lladser… - Advances in cancer …, 2010 - Elsevier
At the present time, regulatory T cells (Tregs) are an integral part of immunology but the
route from discovery of “suppressive” lymphocytes in the 1980s to the current established …
route from discovery of “suppressive” lymphocytes in the 1980s to the current established …
Immunotherapy Against HPV16/18 Generates Potent TH1 and Cytotoxic Cellular Immune Responses
ML Bagarazzi, J Yan, MP Morrow, X Shen… - Science translational …, 2012 - science.org
Despite the development of highly effective prophylactic vaccines against human
papillomavirus (HPV) serotypes 16 and 18, prevention of cervical dysplasia and cancer in …
papillomavirus (HPV) serotypes 16 and 18, prevention of cervical dysplasia and cancer in …
Regulatory T cells in the control of host-microorganism interactions
Each microenvironment requires a specific set of regulatory elements that are finely and
constantly tuned to maintain local homeostasis. Various populations of regulatory T cells …
constantly tuned to maintain local homeostasis. Various populations of regulatory T cells …
Clinician's guide to human papillomavirus immunology: knowns and unknowns
Oncogenic human papillomavirus (HPV) is a common genital infection that has the potential
to develop into cervical cancer in some women. This Review summarises current knowledge …
to develop into cervical cancer in some women. This Review summarises current knowledge …
Role of innate immunity against human papillomavirus (HPV) infections and effect of adjuvants in promoting specific immune response
A Amador-Molina, JF Hernández-Valencia, E Lamoyi… - Viruses, 2013 - mdpi.com
During the early stages of human papillomavirus (HPV) infections, the innate immune
system creates a pro-inflammatory microenvironment by recruiting innate immune cells to …
system creates a pro-inflammatory microenvironment by recruiting innate immune cells to …
Therapeutic HPV vaccines
G Hancock, K Hellner, L Dorrell - … practice & research Clinical obstetrics & …, 2018 - Elsevier
Highlights•Current prophylactic vaccines protect only against infection with high risk types
HPV16 and 18.•Several new platform technologies are being applied to the development of …
HPV16 and 18.•Several new platform technologies are being applied to the development of …
Regulatory T cells and treatment of cancer
TJ Curiel - Current opinion in immunology, 2008 - Elsevier
CD4+ CD25+ FOXP3+ regulatory T cells (Tregs) are elevated in cancers and can thwart
protective antitumor immunity. Recent human cancer trials suggest that depleting Tregs can …
protective antitumor immunity. Recent human cancer trials suggest that depleting Tregs can …
High and Interrelated Rates of PD-L1+CD14+ Antigen-Presenting Cells and Regulatory T Cells Mark the Microenvironment of Metastatic Lymph Nodes from Patients …
AM Heeren, BD Koster, S Samuels, DM Ferns… - Cancer immunology …, 2015 - AACR
A better understanding of the microenvironment in relation to lymph node metastasis is
essential for the development of effective immunotherapeutic strategies against cervical …
essential for the development of effective immunotherapeutic strategies against cervical …