Overview of the 2022 WHO classification of neuroendocrine neoplasms
In this review, we detail the changes and the relevant features that are applied to
neuroendocrine neoplasms (NENs) in the 2022 WHO Classification of Endocrine and …
neuroendocrine neoplasms (NENs) in the 2022 WHO Classification of Endocrine and …
Genomics of high-grade neuroendocrine neoplasms: well-differentiated neuroendocrine tumor with high-grade features (G3 NET) and neuroendocrine carcinomas …
High-grade neuroendocrine neoplasms (HG-NENs) are clinically aggressive diseases, the
classification of which has recently been redefined. They now include both poorly …
classification of which has recently been redefined. They now include both poorly …
Non-functional pancreatic neuroendocrine tumours: ATRX/DAXX and alternative lengthening of telomeres (ALT) are prognostically independent from ARX/PDX1 …
Objective Recent studies have found aristaless-related homeobox gene (ARX)/pancreatic
and duodenal homeobox 1 (PDX1), alpha-thalassemia/mental retardation X-linked …
and duodenal homeobox 1 (PDX1), alpha-thalassemia/mental retardation X-linked …
Epigenetic landscape of pancreatic neuroendocrine tumours reveals distinct cells of origin and means of tumour progression
A Di Domenico, CP Pipinikas, RS Maire… - Communications …, 2020 - nature.com
Recent data suggest that Pancreatic Neuroendocrine Tumours (PanNETs) originate from α-
or β-cells of the islets of Langerhans. The majority of PanNETs are non-functional and do not …
or β-cells of the islets of Langerhans. The majority of PanNETs are non-functional and do not …
[HTML][HTML] Glutamine deprivation induces ferroptosis in pancreatic cancer cells: Glutamine deprivation induces pancreatic cancer ferroptosis
Z **ao, S Deng, H Liu, R Wang, Y Liu… - Acta Biochimica et …, 2023 - ncbi.nlm.nih.gov
Ferroptosis is a type of programmed cell death closely related to amino acid metabolism.
Pancreatic cancer cells have a strong dependence on glutamine, which serves as a carbon …
Pancreatic cancer cells have a strong dependence on glutamine, which serves as a carbon …
[HTML][HTML] Gastrinoma
RT Jensen, T Ito - Endotext [Internet], 2023 - ncbi.nlm.nih.gov
Gastrinomas are neuroendocrine neoplasms (NENs), that occur primarily in the duodenum
and pancreas, which ectopically secrete gastrin, resulting in the Zollinger-Ellison syndrome …
and pancreas, which ectopically secrete gastrin, resulting in the Zollinger-Ellison syndrome …
[HTML][HTML] Immune landscape, evolution, hypoxia-mediated viral mimicry pathways and therapeutic potential in molecular subtypes of pancreatic neuroendocrine …
Objective A comprehensive analysis of the immune landscape of pancreatic neuroendocrine
tumours (PanNETs) was performed according to clinicopathological parameters and …
tumours (PanNETs) was performed according to clinicopathological parameters and …
Alternative lengthening of telomeres and differential expression of endocrine transcription factors distinguish metastatic and non-metastatic insulinomas
WM Hackeng, W Schelhaas, FHM Morsink… - Endocrine …, 2020 - Springer
Insulin-producing pancreatic neuroendocrine tumors (PanNETs)/insulinomas are generally
considered to be indolent tumors with an excellent prognosis after complete resection …
considered to be indolent tumors with an excellent prognosis after complete resection …
Spatiotemporal heterogeneity and clinical challenge of pancreatic neuroendocrine tumors
X Lou, Y Qin, X Xu, X Yu, S Ji - … et Biophysica Acta (BBA)-Reviews on …, 2022 - Elsevier
During the course of pancreatic neuroendocrine tumors (NETs), they generally become
more heterogeneous with individual cells exhibiting distinct molecular fingerprints. This …
more heterogeneous with individual cells exhibiting distinct molecular fingerprints. This …
[HTML][HTML] Liquid biopsy and preclinical tools for advancing diagnosis and treatment of patients with pancreatic neuroendocrine neoplasms
B Smolkova, A Kataki, J Earl, I Ruz-Caracuel… - Critical Reviews in …, 2022 - Elsevier
Pancreatic neuroendocrine neoplasms (pNENs) are rare cancers with broad challenges for
their management. The main clinical obstacles are the high rate of patients diagnosed at …
their management. The main clinical obstacles are the high rate of patients diagnosed at …