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HIV-1 pathogenesis: the virus
Transmission of HIV-1 results in the establishment of a new infection, typically starting from a
single virus particle. That virion replicates to generate viremia and persistent infection in all …
single virus particle. That virion replicates to generate viremia and persistent infection in all …
[HTML][HTML] HIV persistence: silence or resistance?
Despite decades of suppressive antiretroviral therapy, human immunodeficiency virus (HIV)
reservoirs in infected individuals persist and fuel viral rebound once therapy is interrupted …
reservoirs in infected individuals persist and fuel viral rebound once therapy is interrupted …
Differences in HIV burden and immune activation within the gut of HIV-positive patients receiving suppressive antiretroviral therapy
Background. The gut is a major reservoir for human immunodeficiency virus (HIV) in patients
receiving antiretroviral therapy (ART). We hypothesized that distinct immune environments …
receiving antiretroviral therapy (ART). We hypothesized that distinct immune environments …
Cohort profile: the Swiss HIV Cohort study
Swiss HIV Cohort Study… - International journal …, 2010 - academic.oup.com
The Swiss HIV Cohort study (SHCS) was established in 1988. It is an ongoing multicentre,
prospective observational study for interdisciplinary human immunodeficiency virus (HIV) …
prospective observational study for interdisciplinary human immunodeficiency virus (HIV) …
HIV rebounds from latently infected cells, rather than from continuing low-level replication
Rapid rebound of plasma viremia in patients after interruption of long-term combination
antiretroviral therapy (cART) suggests persistence of low-level replicating cells or rapid …
antiretroviral therapy (cART) suggests persistence of low-level replicating cells or rapid …
Long-term persistence of transcriptionally active 'defective'HIV-1 proviruses: implications for persistent immune activation during antiretroviral therapy
K Singh, V Natarajan, R Dewar, A Rupert, Y Badralmaa… - Aids, 2023 - journals.lww.com
Objectives: People with HIV-1 (PWH) on effective antiretroviral therapy (ART) continue to
exhibit chronic systemic inflammation, immune activation, and persistent elevations in …
exhibit chronic systemic inflammation, immune activation, and persistent elevations in …
Effect of raltegravir-containing intensification on HIV burden and T-cell activation in multiple gut sites of HIV-positive adults on suppressive antiretroviral therapy
Objective: To determine whether raltegravir-containing antiretroviral therapy (ART)
intensification reduces HIV levels in the gut. Design: Open-label study in HIV-positive adults …
intensification reduces HIV levels in the gut. Design: Open-label study in HIV-positive adults …
[HTML][HTML] HIV persistence in the setting of antiretroviral therapy: when, where and how does HIV hide?
Advances in the treatment of HIV infection have dramatically reduced the death rate from
AIDS and improved the quality of life of many HIV-infected individuals. However, the …
AIDS and improved the quality of life of many HIV-infected individuals. However, the …
A Novel Single-Cell FISH-Flow Assay Identifies Effector Memory CD4+ T cells as a Major Niche for HIV-1 Transcription in HIV-Infected Patients
Cells that actively transcribe HIV-1 have been defined as the “active viral reservoir” in HIV-
infected individuals. However, important technical limitations have precluded the …
infected individuals. However, important technical limitations have precluded the …
Cell-associated HIV-1 RNA predicts viral rebound and disease progression after discontinuation of temporary early ART
Plasma viral load (VL) and CD4+ T cell count are widely used as biomarkers of HIV type 1
(HIV-1) replication, pathogenesis, and response to antiretroviral therapy (ART). However …
(HIV-1) replication, pathogenesis, and response to antiretroviral therapy (ART). However …