Linking environmental risk factors with epigenetic mechanisms in Parkinson's disease

M Tsalenchuk, SM Gentleman, SJ Marzi - npj Parkinson's Disease, 2023 - nature.com
Sporadic Parkinson's disease (PD) is a progressive neurodegenerative disease, with a
complex risk structure thought to be influenced by interactions between genetic variants and …

DNA methylation: a promising approach in management of Alzheimer's disease and other neurodegenerative disorders

G Kaur, SSS Rathod, MM Ghoneim, S Alshehri… - Biology, 2022 - mdpi.com
Simple Summary DNA methylation is an epigenetic modification of genes which affects
corresponding gene expression. During the developmental stage, embryonic stem cells …

Neuroepigenetics of ageing and neurodegeneration-associated dementia: An updated review

FA Mir, A Amanullah, BP Jain, Z Hyderi… - Ageing Research …, 2023 - Elsevier
Gene expression is tremendously altered in the brain during memory acquisition, recall, and
forgetfulness. However, non-genetic factors, including environmental elements, epigenetic …

Genetic variation and pesticide exposure influence blood DNA methylation signatures in females with early-stage Parkinson's disease

SL Schaffner, W Casazza, F Artaud, C Konwar… - npj Parkinson's …, 2024 - nature.com
Although sex, genetics, and exposures can individually influence risk for sporadic
Parkinson's disease (PD), the joint contributions of these factors to the epigenetic etiology of …

An Overview of Epigenetic Changes in the Parkinson's Disease Brain

A Klokkaris, A Migdalska-Richards - International Journal of Molecular …, 2024 - mdpi.com
Parkinson's disease is a progressive neurodegenerative disorder, predominantly of the
motor system. Although some genetic components and cellular mechanisms of Parkinson's …

[HTML][HTML] Mitochondrial stress-induced H4K12 hyperacetylation dysregulates transcription in Parkinson's disease

M Huang, H **, V Anantharam… - Frontiers in Cellular …, 2024 - frontiersin.org
Aberrant epigenetic modification has been implicated in the pathogenesis of Parkinson's
disease (PD), which is characterized by the irreversible loss of dopaminergic (DAergic) …

Effect of pesticides on phosphorylation of tau protein, and its influence on Alzheimer's disease

ED Torres-Sánchez, GG Ortiz… - World Journal of …, 2023 - pmc.ncbi.nlm.nih.gov
Alzheimer's disease (AD) is a progressive and neurodegenerative illness which results in
alterations in cognitive development. It is characterized by loss/dysfunction of cholinergic …

[HTML][HTML] Exposure to Metals, Pesticides, and Air Pollutants: Focus on Resulting DNA Methylation Changes in Neurodegenerative Diseases

A Stoccoro, F Coppedè - Biomolecules, 2024 - mdpi.com
Individuals affected by neurodegenerative diseases, including Alzheimer's disease (AD),
Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS), are dramatically …

[HTML][HTML] Molecular and cellular interactions in pathogenesis of sporadic Parkinson disease

LP Dolgacheva, VP Zinchenko… - International Journal of …, 2022 - mdpi.com
An increasing number of the population all around the world suffer from age-associated
neurodegenerative diseases including Parkinson's disease (PD). This disorder presents …