Mitochondria are signaling organelles that regulate a wide variety of cellular functions and
can dictate cell fate. Multiple mechanisms contribute to communicate mitochondrial fitness to …

Mammals have two specialized vascular circulatory systems: the blood vasculature and the
lymphatic vasculature. The lymphatic vasculature is a unidirectional conduit that returns …

Glioblastoma multiforme (GBM) remains the top challenge to radiotherapy with only 25%
one-year survival after diagnosis. Here, we reveal that co-enhancement of mitochondrial …

Long-chain fatty acids (FAs) are components of plasma membranes and an efficient fuel
source and also serve as metabolic regulators through FA signaling mediated by membrane …

The lymphatic system, composed of initial and collecting lymphatic vessels as well as lymph
nodes that are present in almost every tissue of the human body, acts as an essential …

Obesity is associated with both increased cancer incidence and progression in multiple
tumour types, and is estimated to contribute to up to 20% of cancer-related deaths. These …

BACKGROUND Blood and lymphatic vessel networks form two arms of the vertebrate
cardiovascular system that play complementary roles in body homeostasis maintenance and …

In 2009, it was postulated that endothelial cells (ECs) would only be able to execute the
orders of growth factors if these cells would accordingly adapt their metabolism. Ten years …

Reversible, spatial, and temporal regulation of metabolic reprogramming and epigenetic
homeostasis are prominent hallmarks of carcinogenesis. Cancer cells reprogram their …

Patients with bladder cancer (BCa) with clinical lymph node (LN) metastasis have an
extremely poor prognosis. VEGF-C has been demonstrated to play vital roles in LN …