Pyrazolo [3, 4-b] pyridines are a group of heterocyclic compounds presenting two possible
tautomeric forms: the 1 H-and 2 H-isomers. More than 300,000 1 H-pyrazolo [3, 4-b] …

The copper (I)-catalyzed 1, 3-dipolar cycloaddition between alkynes and azides (click
chemistry) to form 1, 2, 3-triazoles is the most popular reaction due to its reliability …

Bcr-AblT315I mutation-induced imatinib resistance remains a major challenge for clinical
management of chronic myelogenous leukemia (CML). Herein, we report GZD824 (10a) as …

(+)-Usnic acid, a product of secondary metabolism in lichens, has displayed a broad range
of biological properties such as antitumor, antimicrobial, antiviral, anti-inflammatory, and …

Discoidin domain receptor 1 (DDR1) is an emerging potential molecular target for new
anticancer drug discovery. We have discovered a series of 3-(2-(pyrazolo [1, 5-a] pyrimidin-6 …

An efficient and regioselective cyclization for construction of pyrazolo [3, 4‐b] pyridines and
methylene‐bridged bis (pyrazolo [1, 5‐a] pyrimidines) has been established. It involves a [3+ …

Abstract Discoidin domain receptor 1 (DDR1) is a collagen-activated receptor tyrosine
kinase (RTK) and plays pivotal roles in regulating cellular functions such as proliferation …

Development of tyrosine kinase inhibitors (TKIs) targeting the BCR-ABL oncogene
constitutes an effective approach for the treatment of chronic myeloid leukemia (CML) and/or …

The review deals with the pharmaceutically and agrochemically important group of 1, 2, 4-
triazolo [1, 5-a] pyrimidines (TPs) and covers relevant literature published from about 2006 …

Abstract Pyrazolo [1, 5-a] pyrimidine-containing compounds are an important and strategic N-
heterocycle family because of their proven applicability and synthetic versatility in preparing …