The ingenious mast cell: Contemporary insights into mast cell behavior and function
Mast cells are (in) famous for their role in allergic diseases, but the physiological and
pathophysiological roles of this ingenious cell are still not fully understood. Mast cells are …
pathophysiological roles of this ingenious cell are still not fully understood. Mast cells are …
Hematopoiesis and mast cell development
Hematopoietic stem cells (HSCs) are defined based on their capacity to replenish
themselves (self-renewal) and give rise to all mature hematopoietic cell types (multi-lineage …
themselves (self-renewal) and give rise to all mature hematopoietic cell types (multi-lineage …
A time-and single-cell-resolved model of murine bone marrow hematopoiesis
I Kucinski, J Campos, M Barile, F Severi, N Bohin… - Cell stem cell, 2024 - cell.com
The paradigmatic hematopoietic tree model is increasingly recognized to be limited, as it is
based on heterogeneous populations largely defined by non-homeostatic assays testing cell …
based on heterogeneous populations largely defined by non-homeostatic assays testing cell …
Gut microbiota facilitate chronic spontaneous urticaria
L Zhu, X Jian, B Zhou, R Liu, M Muñoz, W Sun… - Nature …, 2024 - nature.com
Chronic spontaneous urticaria (CSU) comes with gut dysbiosis, but its relevance remains
elusive. Here we use metagenomics sequencing and short-chain fatty acids metabolomics …
elusive. Here we use metagenomics sequencing and short-chain fatty acids metabolomics …
Estrogen mediates inflammatory role of mast cells in endometriosis pathophysiology
Endometriosis is an estrogen dependent, chronic inflammatory disease characterized by the
growth of endometrial lining outside of the uterus. Mast cells have emerged as key players in …
growth of endometrial lining outside of the uterus. Mast cells have emerged as key players in …
Basophils from allergy to cancer
Human basophils, first identified over 140 years ago, account for just 0.5-1% of circulating
leukocytes. While this scarcity long hampered basophil studies, innovations during the past …
leukocytes. While this scarcity long hampered basophil studies, innovations during the past …
Single cell transcriptomics clarifies the basophil differentiation trajectory and identifies pre-basophils upstream of mature basophils
K Miyake, J Ito, J Nakabayashi, S Shichino… - Nature …, 2023 - nature.com
Basophils are the rarest granulocytes and are recognized as critical cells for type 2 immune
responses. However, their differentiation pathway remains to be fully elucidated. Here, we …
responses. However, their differentiation pathway remains to be fully elucidated. Here, we …
Comparative single-cell transcriptional and proteomic atlas of clinical-grade injectable mesenchymal source tissues
S Ruoss, CA Nasamran, ST Ball, JL Chen… - Science …, 2024 - science.org
Bone marrow aspirate concentrate (BMAC) and adipose-derived stromal vascular fraction
(ADSVF) are the most marketed stem cell therapies to treat a variety of conditions in the …
(ADSVF) are the most marketed stem cell therapies to treat a variety of conditions in the …
Association of differential mast cell activation with granulocytic inflammation in severe asthma
Rationale: Mast cells (MCs) play a role in inflammation and both innate and adaptive
immunity, but their involvement in severe asthma (SA) remains undefined. Objectives: We …
immunity, but their involvement in severe asthma (SA) remains undefined. Objectives: We …
Defining mast cell differentiation and heterogeneity through single-cell transcriptomics analysis
Mast cells (MCs) are widely recognized as central effector cells during type 2 inflammatory
reactions and thought to also play a role in innate immune responses, wound healing, and …
reactions and thought to also play a role in innate immune responses, wound healing, and …