Following antigen encounter and subsequent resolution of the immune response, a single
naïve T cell is able to generate multiple subsets of memory T cells with different phenotypic …

T cells mediate effector functions through a variety of mechanisms. Recently, multiparameter
flow cytometry has allowed a simultaneous assessment of the phenotype and multiple …

Protective immunity against influenza virus infection is mediated by neutralizing antibodies,
but the precise role of T cells in human influenza immunity is uncertain. We conducted …

Viruses that cause chronic infection constitute a stable but little-recognized part of our
metagenome: our virome. Ongoing immune responses hold these chronic viruses at bay …

CD4+ T cells with cytotoxic activity (CD4 CTL) have been observed in various immune
responses. These cells are characterized by their ability to secrete granzyme B and perforin …

Following primary infection, human cytomegalovirus (HCMV) establishes lifelong latency
and periodically reactivates without causing symptoms in healthy individuals. In the absence …

The rapid onset of massive, systemic viral replication during primary HIV or simian
immunodeficiency virus (SIV) infection and the immune evasion capabilities of these viruses …

In vitiligo, cytotoxic T cells infiltrating the perilesional margin are suspected to be involved in
the pathogenesis of the disease. However, it remains to be elucidated whether these T cells …

Cancer vaccines are designed to promote tumor specific immune responses, particularly
cytotoxic CD8 positive T cells that are specific to tumor antigens. The earliest vaccines …

A diverse and well-balanced repertoire of T cells is thought to be crucial for the efficacious
defence against infection with new or re-emerging pathogens throughout life. In the last third …