Local immune recognition of trophoblast in early human pregnancy: controversies and questions

A Moffett, N Shreeve - Nature Reviews Immunology, 2023 - nature.com
The role of the maternal immune system in reproductive success in humans remains
controversial. Here we focus on the events that occur in the maternal decidua during the first …

The natural cytotoxicity receptors in health and disease

AD Barrow, CJ Martin, M Colonna - Frontiers in immunology, 2019 - frontiersin.org
The Natural Cytotoxicity Receptors (NCRs), NKp46, NKp44, and NKp30, were some of the
first human activating Natural Killer (NK) cell receptors involved in the non-MHC-restricted …

[HTML][HTML] Multi-tissue single-cell analysis deconstructs the complex programs of mouse natural killer and type 1 innate lymphoid cells in tissues and circulation

AP McFarland, A Yalin, SY Wang, VS Cortez… - Immunity, 2021 - cell.com
Natural killer (NK) cells and type 1 innate lymphoid cells (ILC1s) are heterogenous innate
lymphocytes broadly defined in mice as Lin− NK1. 1+ NKp46+ cells that express the …

Uterine natural killer cells

DK Sojka, L Yang, WM Yokoyama - Frontiers in immunology, 2019 - frontiersin.org
Natural killer (NK) cells are members of a rapidly expanding family of innate lymphoid cells
(ILCs). While most previously studied NK cells were derived from the mouse spleen and …

Biology and pathology of the uterine microenvironment and its natural killer cells

F Wang, AE Qualls, L Marques-Fernandez… - Cellular & molecular …, 2021 - nature.com
Tissues are the new frontier of discoveries in immunology. Cells of the immune system are
an integral part of tissue physiology and immunity. Determining how immune cells inhabit …

How do uterine natural killer and innate lymphoid cells contribute to successful pregnancy?

O Huhn, X Zhao, L Esposito, A Moffett… - Frontiers in …, 2021 - frontiersin.org
Innate lymphoid cells (ILCs) are the most abundant immune cells in the uterine mucosa both
before and during pregnancy. Circumstantial evidence suggests they play important roles in …

Distinctive phenotypes and functions of innate lymphoid cells in human decidua during early pregnancy

O Huhn, MA Ivarsson, L Gardner, M Hollinshead… - Nature …, 2020 - nature.com
During early pregnancy, decidual innate lymphoid cells (dILCs) interact with surrounding
maternal cells and invading fetal extravillous trophoblasts (EVT). Here, using mass …

Tissue-resident lymphocytes: from adaptive to innate immunity

H Sun, C Sun, W **ao, R Sun - Cellular & Molecular Immunology, 2019 - nature.com
Efficient immune responses against invading pathogens often involve coordination between
cells from both the innate and adaptive immune systems. For multiple decades, it has been …

Immunobiology of acute chorioamnionitis

M Cappelletti, P Presicce, SG Kallapur - Frontiers in immunology, 2020 - frontiersin.org
Acute chorioamnionitis is characterized by neutrophilic infiltration and inflammation at the
maternal fetal interface. It is a relatively common complication of pregnancy and can have …

Natural killer cells in the human uterine mucosa

V Male, A Moffett - Annual Review of Immunology, 2023 - annualreviews.org
The presence of granulated lymphocytes in the human uterine mucosa, known as decidua
during pregnancy, or endometrium otherwise, was first noted in the nineteenth century, but it …