Next-generation, personalised, model-based critical care medicine: a state-of-the art review of in silico virtual patient models, methods, and cohorts, and how to …
Critical care, like many healthcare areas, is under a dual assault from significantly
increasing demographic and economic pressures. Intensive care unit (ICU) patients are …
increasing demographic and economic pressures. Intensive care unit (ICU) patients are …
Personalizing mechanical ventilation according to physiologic parameters to stabilize alveoli and minimize ventilator induced lung injury (VILI)
GF Nieman, J Satalin, P Andrews, H Aiash… - Intensive care medicine …, 2017 - Springer
It has been shown that mechanical ventilation in patients with, or at high-risk for, the
development of acute respiratory distress syndrome (ARDS) can be a double-edged sword …
development of acute respiratory distress syndrome (ARDS) can be a double-edged sword …
Quantifying ventilator unloading in CPAP ventilation
Background The intrinsic (muscular) patient effort driving inspiration in non-invasive
ventilation modes, such as continuous positive airway pressure (CPAP) therapy, has not …
ventilation modes, such as continuous positive airway pressure (CPAP) therapy, has not …
Airflow and dynamic circumference of abdomen and thorax for adults at varied continuous positive airway pressure ventilation settings and breath rates
Continuous positive airway pressure (CPAP) ventilation is a commonly prescribed
respiratory therapy providing positive end-expiratory pressure (PEEP) to assist breathing …
respiratory therapy providing positive end-expiratory pressure (PEEP) to assist breathing …
Optimising mechanical ventilation through model-based methods and automation
Mechanical ventilation (MV) is a core life-support therapy for patients suffering from
respiratory failure or acute respiratory distress syndrome (ARDS). Respiratory failure is a …
respiratory failure or acute respiratory distress syndrome (ARDS). Respiratory failure is a …
Time-varying respiratory system elastance: a physiological model for patients who are spontaneously breathing
Background Respiratory mechanics models can aid in optimising patient-specific
mechanical ventilation (MV), but the applications are limited to fully sedated MV patients …
mechanical ventilation (MV), but the applications are limited to fully sedated MV patients …
An identifiable model of lung mechanics to diagnose and monitor COPD
Background: Current methods to diagnose and monitor COPD employ spirometry as the
gold standard to identify lung function reduction with reduced forced expiratory volume (FEV …
gold standard to identify lung function reduction with reduced forced expiratory volume (FEV …
The Clinical Utilisation of Respiratory Elastance Software (CURE Soft): a bedside software for real-time respiratory mechanics monitoring and mechanical ventilation …
Background Real-time patient respiratory mechanics estimation can be used to guide
mechanical ventilation settings, particularly, positive end-expiratory pressure (PEEP). This …
mechanical ventilation settings, particularly, positive end-expiratory pressure (PEEP). This …
Over-distension prediction via hysteresis loop analysis and patient-specific basis functions in a virtual patient model
Background and objective Recruitment maneuvers (RMs) with subsequent positive-end-
expiratory-pressure (PEEP) have proven effective in recruiting lung volume and preventing …
expiratory-pressure (PEEP) have proven effective in recruiting lung volume and preventing …
Model-based estimation of negative inspiratory driving pressure in patients receiving invasive NAVA mechanical ventilation
Background Optimisation of mechanical ventilation (MV) and weaning requires insight into
underlying patient breathing effort. Current identifiable models effectively describe lung …
underlying patient breathing effort. Current identifiable models effectively describe lung …