In all eukaryotes, the target of rapamycin (TOR) signalling pathway couples energy and
nutrient abundance to the execution of cell growth and division, owing to the ability of TOR …

When the food intake of organisms such as yeast and rodents is reduced (dietary restriction),
they live longer than organisms fed a normal diet. A similar effect is seen when the activity of …

Many experts in the biology of ageing believe that pharmacological interventions to slow
ageing are a matter of'when'rather than'if'. A leading target for such interventions is the …

The nematode Caenorhabditis elegans ages and dies in a few weeks, but humans can live
for 100 years or more. Assuming that the ancestor we share with nematodes aged rapidly …

Inhibition of the protein kinase mechanistic target of rapamycin (mTOR) with the Food and
Drug Administration (FDA)-approved therapeutic rapamycin promotes health and longevity …

Abstract TOR (T arget O f R apamycin) is a highly conserved protein kinase that is important
in both fundamental and clinical biology. In fundamental biology, TOR is a nutrient-sensitive …

Saccharomyces cerevisiae has directly or indirectly contributed to the identification of
arguably more mammalian genes that affect aging than any other model organism. Aging in …

Gut bacteria occupy the interface between the organism and the external environment,
contributing to homeostasis and disease. Yet, the causal role of the gut microbiota during …

Target of rapamycin (TOR) is an evolutionarily conserved nutrient-sensing protein kinase
that regulates growth and metabolism in all eukaryotic cells. Studies in flies, worms, yeast …

Rapamycin, an inhibitor of mechanistic target of rapamycin (mTOR), has the strongest
experimental support to date as a potential anti-aging therapeutic in mammals. Unlike many …