Optimizing separations in online comprehensive two‐dimensional liquid chromatography

BWJ Pirok, AFG Gargano… - Journal of separation …, 2018 - Wiley Online Library
Online comprehensive two‐dimensional liquid chromatography has become an attractive
option for the analysis of complex nonvolatile samples found in various fields (eg …

Comprehensive two-dimensional liquid chromatography

L Mondello, P Dugo, P Donato, M Herrero… - Nature Reviews …, 2023 - nature.com
Despite progress in hardware and column technology, the complexity and heterogeneity of
many samples still pose a challenge for state-of-the-art 1D liquid chromatography (LC). As …

Review of three-dimensional liquid chromatography platforms for bottom-up proteomics

VA Duong, JM Park, H Lee - International Journal of Molecular Sciences, 2020 - mdpi.com
Proteomics is a large-scale study of proteins, aiming at the description and characterization
of all expressed proteins in biological systems. The expressed proteins are typically highly …

Analysis of host-cell proteins in biotherapeutic proteins by comprehensive online two-dimensional liquid chromatography/mass spectrometry

C Doneanu, A Xenopoulos, K Fadgen, J Murphy… - MAbs, 2012 - Taylor & Francis
Assays for identification and quantification of host-cell proteins (HCPs) in biotherapeutic
proteins over 5 orders of magnitude in concentration are presented. The HCP assays consist …

Foodomics evaluation of bioactive compounds in foods

A Valdés, A Cifuentes, C León - TrAC Trends in Analytical Chemistry, 2017 - Elsevier
Foodomics involves the study of food and nutrition domains through the application and
integration of advanced omics technologies, such as transcriptomics, proteomics and …

Two-dimensional liquid chromatography approaches in Foodomics–a review

L Montero, M Herrero - Analytica Chimica Acta, 2019 - Elsevier
Modern food analysis is directed to the characterization of as many components as possible
in food and food-related materials. The use of–omics technologies within a Foodomics …

Determination of phospholipids in milk samples by means of hydrophilic interaction liquid chromatography coupled to evaporative light scattering and mass …

P Donato, F Cacciola, F Cichello, M Russo… - … of Chromatography A, 2011 - Elsevier
The combined use of the state-of-the-art hybrid mass spectrometers together with high
efficient liquid chromatography could surely be a useful tool for such a challenging task, as …

Multidimensional liquid chromatography in food analysis

F Cacciola, P Dugo, L Mondello - TrAC Trends in Analytical Chemistry, 2017 - Elsevier
Multidimensional techniques are still an expanding niche in separation science, due to their
undoubtedly increased separation power over “conventional” one-dimensional systems in …

Challenges in polymer analysis by liquid chromatography

E Uliyanchenko, S van der Wal… - Polymer Chemistry, 2012 - pubs.rsc.org
Synthetic polymers are very important in our daily life. Many valuable properties of polymers
are determined by their molecular weight and chemical composition. Liquid …

Comprehensive two-dimensional liquid chromatography of therapeutic monoclonal antibody digests

G Vanhoenacker, I Vandenheede, F David… - Analytical and …, 2015 - Springer
Comprehensive two-dimensional liquid chromatography (LC× LC) is here proposed as a
novel tool for peptide map** of therapeutic monoclonal antibodies in both R&D and …