Recent advances in isatin hybrids as potential anticancer agents
Z Ding, M Zhou, C Zeng - Archiv der Pharmazie, 2020 - Wiley Online Library
The isatin framework is a useful template for the development of novel anticancer agents.
This is exemplified by the fact that several isatin‐based anticancer agents, such as …
This is exemplified by the fact that several isatin‐based anticancer agents, such as …
Chemical and biological evaluation of thiosemicarbazone-bearing heterocyclic metal complexes
Thiosemicarbazones (TSCNs) constitute a broad family of compounds (R1R2C= N-NH-C (S)-
NR3R4), particularly attractive because many of them display some biological activity …
NR3R4), particularly attractive because many of them display some biological activity …
Synthesis of a novel hydrazone-based compound applied as a fluorescence turn-on chemosensor for iron (iii) and a colorimetric sensor for copper (ii) with …
Hydrazone–hydrazide-based linkers perform a crucial role in environmental as well as
biological fields. Such linkers are employed to detect exact metal ions at a minute level; …
biological fields. Such linkers are employed to detect exact metal ions at a minute level; …
Synthesis and characterization of N4-substituted thiosemicarbazones: DNA/BSA binding, molecular docking, anticancer activity, ADME study and computational …
A series of thiosemicarbazones with the general formula, R− CHdouble bondN− NH− C (S)−
R 1 [R= C 6 H 5 F & R 1= C 4 H 9 NO (TL1), R= C 8 H 10 O 2 & R 1= C 4 H 9 NO (TL2), R= C …
R 1 [R= C 6 H 5 F & R 1= C 4 H 9 NO (TL1), R= C 8 H 10 O 2 & R 1= C 4 H 9 NO (TL2), R= C …
Synthesis, spectroscopic characterizations, single crystal X-ray analysis, DFT calculations, in vitro biological evaluation and in silico evaluation studies of …
VNV Palakkeezhillam, J Haribabu… - Journal of Molecular …, 2023 - Elsevier
We created new thiosemicarbazones and their cyclized heterocyclic compounds, examined
them, and evaluated their biological activity in silico and in vitro. Two pyrene-based …
them, and evaluated their biological activity in silico and in vitro. Two pyrene-based …
Exploring the anticancer potential of thiadiazole derivatives of substituted thiosemicarbazones formed via copper‐mediated cyclization
VN Vadakkedathu Palakkeezhillam… - Applied …, 2023 - Wiley Online Library
A couple of N‐(4)‐morpholine/pyrrolidine‐substituted thiosemicarbazones (TSCs) of
fluorene‐2‐carboxaldehyde (FM and FP), and their corresponding thiadiazoles (TDZs)(CFM …
fluorene‐2‐carboxaldehyde (FM and FP), and their corresponding thiadiazoles (TDZs)(CFM …
Therapeutic perspective of thiosemicarbazones derivatives in inflammatory pathologies: A summary of in vitro/in vivo studies
F Kanso, A Khalil, H Noureddine… - International …, 2021 - Elsevier
Following induction of inflammation, the nuclear factor kappa B (NF-κB) in activated
macrophages induces the transcription of pro-inflammatory cytokines such as tumor …
macrophages induces the transcription of pro-inflammatory cytokines such as tumor …
Mechanistic insight and structure activity relationship of isatin-based derivatives in development of anti-breast cancer agents
Breast cancer is most common in women and most difficult to manage that causes highest
mortality and morbidity among all diseases and posing significant threat to mankind as well …
mortality and morbidity among all diseases and posing significant threat to mankind as well …
Biomolecular Interactions and Anticancer Mechanisms of Ru (II)-Arene Complexes of Cinnamaldehyde-Derived Thiosemicarbazone Ligands: Analysis Combining In …
VN Vadakkedathu Palakkeezhillam… - ACS Applied Bio …, 2024 - ACS Publications
Our study focuses on synthesizing and exploring the potential of three N-(4) substituted
thiosemicarbazones derived from cinnamic aldehyde, alongside their Ru (II)-(η6-p …
thiosemicarbazones derived from cinnamic aldehyde, alongside their Ru (II)-(η6-p …
2′-Thiophenecarboxaldehyde derived thiosemicarbazone metal complexes of copper (II), palladium (II) and zinc (II) ions: Synthesis, spectroscopic characterization …
Abstract Heterocyclic 5′-methyl-2-thiophenecarboxaldehyde-N (4)-un/substituted
thiosemicarbazones (1–3) and their metal complexes with copper (II), palladium (II) and zinc …
thiosemicarbazones (1–3) and their metal complexes with copper (II), palladium (II) and zinc …