Incomplete response to Anti-VEGF therapy in neovascular AMD: Exploring disease mechanisms and therapeutic opportunities

PS Mettu, MJ Allingham, SW Cousins - Progress in retinal and eye …, 2021‏ - Elsevier
Intravitreal anti-vascular endothelial growth factor (VEGF) drugs have revolutionized the
treatment of neovascular age-related macular degeneration (NVAMD). However, many …

Towards a better understanding of non-exudative choroidal and macular neovascularization

R Sacconi, S Fragiotta, D Sarraf, SVR Sadda… - Progress in Retinal and …, 2023‏ - Elsevier
Non-exudative macular and choroidal neovascularization (MNV and CNV) usually refers to
the entity of treatment-naïve type 1 neovascularization in the absence of associated signs of …

Efficacy and safety of intravitreal aflibercept treat-and-extend regimens in exudative age-related macular degeneration: 52-and 96-week findings from ALTAIR: a …

M Ohji, K Takahashi, AA Okada, M Kobayashi… - Advances in …, 2020‏ - Springer
Purpose To evaluate efficacy and safety of intravitreal injections of aflibercept (IVT-AFL) treat-
and-extend (T&E) dosing regimens in treatment-naïve patients with exudative age-related …

[HTML][HTML] Application of automated quantification of fluid volumes to anti–VEGF therapy of neovascular age-related macular degeneration

U Schmidt-Erfurth, WD Vogl, LM Jampol, H Bogunović - Ophthalmology, 2020‏ - Elsevier
Purpose Anti–vascular endothelial growth factor (VEGF) treatment of neovascular age-
related macular degeneration (AMD) is a highly effective advance in the retinal armentarium …

[HTML][HTML] Quantitative approaches in multimodal fundus imaging: state of the art and future perspectives

A Arrigo, E Aragona, MB Parodi, F Bandello - Progress in retinal and eye …, 2023‏ - Elsevier
When it first appeared, multimodal fundus imaging revolutionized the diagnostic workup and
provided extremely useful new insights into the pathogenesis of fundus diseases. The recent …

[HTML][HTML] Quantitative analysis of OCT for neovascular age-related macular degeneration using deep learning

G Moraes, DJ Fu, M Wilson, H Khalid, SK Wagner… - Ophthalmology, 2021‏ - Elsevier
Purpose To apply a deep learning algorithm for automated, objective, and comprehensive
quantification of optical coherence tomography (OCT) scans to a large real-world dataset of …

[HTML][HTML] AI-based monitoring of retinal fluid in disease activity and under therapy

U Schmidt-Erfurth, GS Reiter, S Riedl… - Progress in retinal and …, 2022‏ - Elsevier
Retinal fluid as the major biomarker in exudative macular disease is accurately visualized by
high-resolution three-dimensional optical coherence tomography (OCT), which is used …

Associations of variation in retinal thickness with visual acuity and anatomic outcomes in eyes with neovascular age-related macular degeneration lesions treated with …

RN Evans, BC Reeves, MG Maguire… - JAMA …, 2020‏ - jamanetwork.com
Importance When initiating anti–vascular endothelial growth factor (VEGF) treatment for
patients with neovascular age-related macular degeneration (nAMD), knowledge of …

Clinically relevant deep learning for detection and quantification of geographic atrophy from optical coherence tomography: a model development and external …

G Zhang, DJ Fu, B Liefers, L Faes, S Glinton… - The Lancet Digital …, 2021‏ - thelancet.com
Background Geographic atrophy is a major vision-threatening manifestation of age-related
macular degeneration, one of the leading causes of blindness globally. Geographic atrophy …

Treatment regimens for administration of anti‐vascular endothelial growth factor agents for neovascular age‐related macular degeneration

E Li, S Donati, KB Lindsley… - Cochrane Database …, 2020‏ - cochranelibrary.com
Background Age‐related macular degeneration (AMD) is one of the leading causes of
permanent blindness worldwide. The current mainstay of treatment for neovascular AMD …