Biocatalysis integrate microbiologists, enzymologists, and organic chemists to access the
repertoire of pharmaceutical and agrochemicals with high chemoselectivity, regioselectivity …

Enzymes, at the turn of the 21st century, are gaining a momentum. Especially in the field of
synthetic organic chemistry, a broad variety of biocatalysts are being applied in an …

Recent studies of multiple enzyme families collectively called ene-reductases (ERs) have
highlighted potential industrial applications of these biocatalysts in the production of fine and …

Ancestral sequence reconstruction (ASR) has been used to produce enzymes that exhibit
enhanced stability, activity, and promiscuity compared to wild-type (WT) enzymes. In this …

Chemoenzymatic cascade catalysis has emerged as a revolutionary tool for streamlining
traditional retrosynthetic disconnections, creating new possibilities for the asymmetric …

Highlights•OYE homologues (ene-reductases) are widely used for C double bond C-bond
reduction reactions.•Protein diversity screening and protein engineering aim at providing …

Ene‐reductases from the Old Yellow Enzyme (OYE) superfamily are a well‐known and
efficient biocatalytic alternative for the asymmetric reduction of C= C bonds. Considering the …

Enantioselective reduction reactions are privileged transformations for the construction of
trisubstituted stereogenic centers. While these include established synthetic strategies, such …

Ene reductases from the Old Yellow Enzyme (OYE) family reduce the C= C double bond in
α, β‐unsaturated compounds bearing an electron‐withdrawing group, for example, a …

A visible-light-induced palladium-catalyzed Dowd–Beckwith ring expansion/C–C bond
formation cascade is described. A range of six to nine-membered β-alkenylated cyclic …