Utilizing non-coding RNA-mediated regulation of ATP binding cassette (ABC) transporters to overcome multidrug resistance to cancer chemotherapy

KKW To, Z Huang, H Zhang, CR Ashby Jr, L Fu - Drug Resistance Updates, 2024 - Elsevier
Multidrug resistance (MDR) is one of the primary factors that produces treatment failure in
patients receiving cancer chemotherapy. MDR is a complex multifactorial phenomenon …

[HTML][HTML] FOXO1, a tiny protein with intricate interactions: Promising therapeutic candidate in lung cancer

M Ebrahimnezhad, M Natami, GH Bakhtiari… - Biomedicine & …, 2023 - Elsevier
Nowadays, lung cancer is the most common cause of cancer-related deaths in both men
and women globally. Despite the development of extremely efficient targeted agents, lung …

Evaluation of anti-cancer effects of carnosine and melittin-loaded niosomes in MCF-7 and MDA-MB-231 breast cancer cells

MMA Hussein, A Abdelfattah-Hassan… - Frontiers in …, 2023 - frontiersin.org
Background: We investigated the anti-cancer effect of carnosine-loaded niosomes (Car-NIO)
and melittin-loaded niosomes (Mel-NIO) with olaparib in breast cancer cell lines (MCF-7 and …

Infiltrating treg reprogramming in the tumor immune microenvironment and its optimization for immunotherapy

Z Zhou, J Xu, S Liu, Y Lv, R Zhang, X Zhou, Y Zhang… - Biomarker …, 2024 - Springer
Immunotherapy has shown promising anti-tumor effects across various tumors, yet it
encounters challenges from the inhibitory tumor immune microenvironment (TIME) …

The Involvement of Peroxiporins and Antioxidant Transcription Factors in Breast Cancer Therapy Resistance

L Milković, M Mlinarić, I Lučić, A Čipak Gašparović - Cancers, 2023 - mdpi.com
Simple Summary The main problem preventing successful cancer treatment is therapy
resistance. Initially, the membrane pumps were identified as the cause of resistance, but …

[HTML][HTML] Unveiling the potential of FOXO3 in lung cancer: From molecular insights to therapeutic prospects

M Ebrahimnezhad, A Valizadeh, M Majidinia… - Biomedicine & …, 2024 - Elsevier
Lung cancer poses a significant challenge regarding molecular heterogeneity, as it
encompasses a wide range of molecular alterations and cancer-related pathways. Recent …

Design, synthesis and biological evaluation of indazole carboxamide analogues as potential anticancer agents

JR Alla, SK Badampudi, DG Niharika, A Reddy… - Journal of Molecular …, 2025 - Elsevier
Novel indazole carboxamides (3a-j) were synthesized using conventional, catalytic, and
green methods. Their anti-proliferative activities were evaluated through in vitro and in silico …

Evaluation of the expression of LINCOO475 and FOXO1 genes as tumor suppressor genes in breast cancer: Correlation of bioinformatics tools and experimental …

F Motamedi, M Khatami, MM Heidari, M Azadeh… - Gene Reports, 2024 - Elsevier
Breast cancer is one of the most prevalent forms of malignancy in humans and is considered
the most important life-threatening factor among women worldwide. Long non-coding RNAs …

[PDF][PDF] Molecular Insights of Exonal Polymorphism in Cancer Risk

R Kumari, S Ram, MMA Rizvi, M Rani - 2024 - meddocsonline.org
Single nucleotide polymorphisms are a sort of genetic variations, have been identified in
numerous genes that linked to various cancer types. SNPs in exon regions of hub cellular of …