Functional annotation of proteins is a fundamental problem in the post‐genomic era. The
recent availability of protein interaction networks for many model species has spurred on the …

Map** protein–protein interactions is an invaluable tool for understanding protein
function. Here, we report the first large‐scale study of protein–protein interactions in human …

Testicular germ cell tumours (TGCTs) are the leading cause of cancer deaths in young male
Caucasians. Identifying changes in DNA copy number can pinpoint genes involved in …

Background With the advent of systems biology, biological knowledge is often represented
today by networks. These include regulatory and metabolic networks, protein-protein …

No single experimental method can discover all connections in the interactome. A
computational approach can help by integrating data from multiple, often unrelated …

Background Human protein-protein interaction (PPIs) data are the foundation for
understanding molecular signalling networks and the functional roles of biomolecules …

Combining the mutual information criterion with a forward feature selection strategy offers a
good trade-off between optimality of the selected feature subset and computation time …

Purpose: Prostate cancer remains the second most frequent cause of tumor-related deaths
in the Western world. Additional markers for the identification of prostate cancer …

Background Large-scale identification of the interrelationships between different
components of the cell, such as the interactions between proteins, has recently gained great …

Dosage sensitivity is an important evolutionary force which impacts on gene dispensability
and duplicability. The newly available data on human copy-number variation (CNV) allow an …