Do ionic liquids exhibit the required characteristics to dissolve, extract, stabilize, and purify proteins? Past-present-future assessment

P Bharmoria, AA Tietze, D Mondal, TS Kang… - Chemical …, 2024 - ACS Publications
Proteins are highly labile molecules, thus requiring the presence of appropriate solvents and
excipients in their liquid milieu to keep their stability and biological activity. In this field, ionic …

Recent advances in ionic liquids in biomedicine

AM Curreri, S Mitragotri, EEL Tanner - Advanced Science, 2021 - Wiley Online Library
The use of ionic liquids and deep eutectic solvents in biomedical applications has grown
dramatically in recent years due to their unique properties and their inherent tunability. This …

Hydration in deep eutectic solvents induces non-monotonic changes in the conformation and stability of proteins

A Sanchez-Fernandez, M Basic, J **ang… - Journal of the …, 2022 - ACS Publications
The preservation of labile biomolecules presents a major challenge in chemistry, and deep
eutectic solvents (DESs) have emerged as suitable environments for this purpose. However …

A simple overview of toxicity of ionic liquids and designs of biocompatible ionic liquids

K Kuroda - New Journal of Chemistry, 2022 - pubs.rsc.org
Evaluation of toxicity of ionic liquids has been less prioritized, compared to the development
of new ionic liquids and their applications. Focus on the toxicity of ionic liquids should be …

[HTML][HTML] Ionic liquids as protein stabilizers for biological and biomedical applications: A review

NV Verissimo, FA Vicente, RC de Oliveira… - Biotechnology …, 2022 - Elsevier
Biotechnology has revolutionized science and health care by providing new biomolecules
with biological and medical applications. However, the low stability of several life-saving …

Mechanisms of action of ionic liquids on living cells: The state of the art

P Kumari, VVS Pillai, A Benedetto - Biophysical reviews, 2020 - Springer
Ionic liquids (ILs) are a relatively new class of organic electrolytes composed of an organic
cation and either an organic or inorganic anion, whose melting temperature falls around …

[HTML][HTML] Scattering approaches to unravel protein solution behaviors in ionic liquids and deep eutectic solvents: From basic principles to recent developments

Q Han, NVP Veríssimo, SJ Bryant, AV Martin… - Advances in Colloid and …, 2024 - Elsevier
Proteins in ionic liquids (ILs) and deep eutectic solvents (DESs) have gained significant
attention due to their potential applications in various fields, including biocatalysis …

[HTML][HTML] Alternative excipients for protein stabilization in protein therapeutics: overcoming the limitations of polysorbates

AJ Castañeda Ruiz, MA Shetab Boushehri, T Phan… - Pharmaceutics, 2022 - mdpi.com
Given their safety and efficiency in protecting protein integrity, polysorbates (PSs) have been
the most widely used excipients for the stabilization of protein therapeutics for years. In …

Use of ionic liquids in protein and DNA chemistry

SK Shukla, JP Mikkola - Frontiers in Chemistry, 2020 - frontiersin.org
Ionic liquids (ILs) have been receiving much attention as solvents in various areas of
biochemistry because of their various beneficial properties over the volatile solvents and ILs …

Optimization of immobilized urease enzyme on porous polymer for enhancing the stability, reusability and enzymatic kinetics using response surface methodology

B Sahin, B Ozbey-Unal, N Dizge, B Keskinler… - Colloids and Surfaces B …, 2024 - Elsevier
The study examines the immobilization of the urease enzyme on a range of High Internal
Phase Emulsion (polyHIPE) materials, assessing characteristics, efficiency, and …