The recent clinical successes of immunotherapy, as a result of a broader and more profound
understanding of cancer immunobiology, and the leverage of this knowledge to effectively …

The rationale behind cancer immunotherapy is based on the unequivocal demonstration
that the immune system plays an important role in limiting cancer initiation and progression …

Acclaimed by the worldwide medical community as" a staple reference text in the medical
oncologist's library"(JAMA), DeVita, Hellman, and Rosenberg's Cancer: Principles and …

The adoptive transfer of tumor-infiltrating lymphocytes (TIL) expanded in interleukin-2 (IL-2)
to mice bearing micrometastases from various types of tumors showed that TIL are 50 to 100 …

Background: Studies of human tumor-infiltrating lymphocytes (TILs) derived from patients
with a variety of histologic types of cancer have demonstrated that cellular immune reactions …

We studied the effects of adoptive immunotherapy with lymphokine-activated killer (LAK)
cells plus interleukin-2 or therapy with high-dose interleukin-2 alone in 157 patients with …

Abstract Background: Treatment using interleukin-2 (IL-2) alone or in conjunction with
lymphokine-activated killer (LAK) cells has been shown to mediate disease regression in …

Objective and background: Pathological changes in severe acute respiratory syndrome
(SARS) suggest that SARS sequelae are associated with dysregulation of cytokine and …

The development of the T-and natural killer (NK) cell growth factor IL-2 has been a sentinel
force ushering in the era of immunotherapy in cancer. With the advent of clinical grade …

A method was described for the generation of cells from tumor-bearing mice; these cells
were capable of exhibiting significant antitumor reactivity when adoptively transferred into …