Obesity, a burgeoning global health issue, is increasingly recognized for its detrimental
effects on the central nervous system, particularly concerning the integrity of the blood-brain …

The blood-brain barrier (BBB) serves as a defensive line protecting the central nervous
system, while also maintaining micro-environment homeostasis and inhibiting harmful …

Human induced pluripotent stem cell (hiPSC) technologies offer a unique resource for
modeling neurological diseases. However, iPSC models are fraught with technical …

Background Neurodegenerative disorders are a group of age-associated diseases
characterized by progressive degeneration of the structure and function of the CNS. Two key …

The extracellular matrix (ECM) is a complex network of biomolecules that mechanically and
biochemically directs cell behavior and is crucial for maintaining tissue function and health …

Tissue engineering is a promising strategy to repair spinal cord injury (SCI). However, a
bioscaffold with mechanical properties that match those of the pathological spinal cord …

T helper (Th) 17 cells are considered to contribute to inflammatory mechanisms in diseases
such as multiple sclerosis (MS). However, the discussion persists regarding their true role in …

Neurovascular pathologies of the central nervous system (CNS), which are associated with
barrier dysfunction, are leading causes of death and disability. The roles that neuronal and …

In the adult brain, synapses are tightly enwrapped by lattices of the extracellular matrix that
consist of extremely long-lived molecules. These lattices are deemed to stabilize synapses …

Brain metastasis is a complication of increasing incidence in patients with breast cancer at
advanced disease stage. It is a severe condition characterized by a rapid decline in quality …