The ultimate form of parasitism and evasion of host immunity is for the parasite genome to
enter the germ line of the host species. Retroviruses have invaded the host germ line on the …

Human Endogenous Retroviruses (HERVs) are accounting for 8% of the human genome.
These sequences are remnants from ancient germline infections by exogenous retroviruses …

SET domain bifurcated 1 (SETDB1), a pivotal histone lysine methyltransferase, is
transported to the cytoplasm via a chromosome region maintenance 1 (CMR1)-dependent …

Epigenetic alterations are implicated in tumour immune evasion and immune checkpoint
blockade (ICB) resistance. SET domain bifurcated histone methyltransferase 1 (SETDB1) is …

ESET/SETDB1, one of the major histone methyltransferases, catalyzes histone 3 lysine 9
(H3K9) trimethylation. ESET is critical for suppressing expression of retroviral elements in …

SET domain bifurcated methyltransferase 1 (SETDB1) serves as a histone lysine
methyltransferase, catalyzing the di-and tri-methylation of histone H3K9. Mounting evidence …

ABSTRACT The H3K9me3-specific histone methyltransferase Setdb1 impacts on
transcriptional regulation by repressing both developmental genes and retrotransposons …

The efficacy of anticancer drugs depends on a variety of signaling pathways, which can be
positively or negatively regulated. In this study, we show that SETDB1 HMTase is down …

Non-small cell lung cancer (NSCLC) is the most common type in lung cancer in the world,
and it severely threatens the life of patients. Resveratrol has been reported to inhibit cancer …

T cell development involves stepwise progression through defined stages that give rise to
multiple T cell subtypes, and this is accompanied by the establishment of stage-specific …