Transcriptional noise is proposed to participate in cell fate changes, but contributions to
mammalian cell differentiation systems, including cancer, remain associative. Cancer …

Abstract The Allis group identified Gcn5 as the first transcription-related lysine
acetyltransferase in 1996, providing a molecular 'missing link'between chromatin …

The mammalian epidermis undergoes constant renewal, replenished by a pool of stem cells
and terminal differentiation of their progeny. This is accompanied by changes in gene …

Background Breast cancer (BC) is the most frequent tumor entity in women worldwide with a
high chance of therapeutic response in early-and non-metastatic disease stages. Among all …

Histone acetyltransferases KAT2A and KAT2B are paralogs highly expressed in the
intestinal epithelium, but their functions are not well understood. In this study, double …

Psoriasis is a chronic immune-mediated skin disease in which the symptom-free, uninvolved
skin carries alterations in gene expression, serving as a basis for lesion formation. Histones …

Bone marrow mesenchymal stem cells (BMSCs) play a critical role in bone formation and
are extremely sensitive to external mechanical stimuli. Mechanical signals can regulate the …

Epigenetic histone modifiers are key regulators of cell fate decisions in normal and
malignant hematopoiesis. Their enzymatic activities are of particular significance as putative …

Background and Objectives: The modification of histone acetylation plays a vital role in
regulating tumor occurrence and development, but the interaction between histone …

Simple Summary BET inhibitors (BETis) are a class of promising therapies that inhibit the
growth of melanoma cells. However, how to identify BETi-sensitive subtypes of melanoma is …