History repeating: guidelines to address common problems in psychedelic science
Research in the last decade has expressed considerable optimism about the clinical
potential of psychedelics for the treatment of mental disorders. This optimism is reflected in …
potential of psychedelics for the treatment of mental disorders. This optimism is reflected in …
Pharmacotherapies for treatment-resistant depression: how antipsychotics fit in the rapidly evolving therapeutic landscape
One in three adults with major depressive disorder (MDD) do not experience clinically
significant improvement after multiple sequential courses of antidepressants and have …
significant improvement after multiple sequential courses of antidepressants and have …
Must psilocybin always “assist psychotherapy”?
GM Goodwin, E Malievskaia… - American Journal of …, 2024 - Am Psychiatric Assoc
Design Open-label Randomized Randomized, double-blind, placebo-controlled
Randomized, double-blind, placebo-controlled Randomized, double-blind, placebo …
Randomized, double-blind, placebo-controlled Randomized, double-blind, placebo …
Randomized trial of ketamine masked by surgical anesthesia in patients with depression
TR Lii, AE Smith, JR Flohr, RL Okada… - Nature mental …, 2023 - nature.com
Ketamine may have antidepressant properties, but its acute psychoactive effects complicate
successful masking in placebo-controlled trials. Here we present a single-center, parallel …
successful masking in placebo-controlled trials. Here we present a single-center, parallel …
Psychedelic therapies reconsidered: compounds, clinical indications, and cautious optimism
The clinical investigation of psychedelic medicines has blossomed over the last 5 years.
Data from a Phase 3 industry trial and a multicenter Phase 2 industry trial, in addition to …
Data from a Phase 3 industry trial and a multicenter Phase 2 industry trial, in addition to …
Ketamine in neuropsychiatric disorders: an update
The discovery of ketamine as a rapid-acting antidepressant led to a new era in the
development of neuropsychiatric therapeutics, one characterized by an antidepressant …
development of neuropsychiatric therapeutics, one characterized by an antidepressant …
Rapid neuroplasticity changes and response to intravenous ketamine: a randomized controlled trial in treatment-resistant depression
Intravenous ketamine is posited to rapidly reverse depression by rapidly enhancing
neuroplasticity. In human patients, we quantified gray matter microstructural changes on a …
neuroplasticity. In human patients, we quantified gray matter microstructural changes on a …
Repeated (S)-ketamine administration ameliorates the spatial working memory impairment in mice with chronic pain: role of the gut microbiota–brain axis
Y Jiang, X Wang, J Chen, Y Zhang, K Hashimoto… - Gut …, 2024 - Taylor & Francis
Chronic pain is commonly linked with diminished working memory. This study explores the
impact of the anesthetic (S)-ketamine on spatial working memory in a chronic constriction …
impact of the anesthetic (S)-ketamine on spatial working memory in a chronic constriction …
Choosing Between Ketamine and Electroconvulsive Therapy for Outpatients With Treatment-Resistant Depression—Advantage Ketamine?
This Viewpoint examines key issues stemming from severalrecentreportsofelectroconvulsivether…
(ECT) vs ketamine infusion for improving depressive symptoms in treatment-resistant …
(ECT) vs ketamine infusion for improving depressive symptoms in treatment-resistant …
Ketamine and psychotherapy for the treatment of psychiatric disorders: systematic review
Background Ketamine is an effective short-term treatment for a range of psychiatric
disorders. A key question is whether the addition of psychotherapy to ketamine treatment …
disorders. A key question is whether the addition of psychotherapy to ketamine treatment …