Pyridines and pyrimidines are the class of heterocyclic nitrogenous compounds having
plethora of applications in anticancer drug development. These synthetic sources serve as …

Recently, in silico techniques have gained tremendous popularity in the field of small
molecule drug discovery. The computational jobs include not only hit generation, lead …

Pyrazolo [1, 5-a] pyrimidine (PP) derivatives are an enormous family of N-heterocyclic
compounds that possess a high impact in medicinal chemistry and have attracted a great …

Frequent and variant infections are caused by the virtue of opportunistic fungi pathogens.
Candidiasis, aspergillosis, and mucormycosis are pathogenic microorganisms that give rise …

Pyrazole-containing compounds represent one of the most influential families of N-
heterocycles due to their proven applicability and versatility as synthetic intermediates in …

Pyrazolopyrimidine scaffold is one of the privileged heterocycles in drug discovery. This
scaffold produced numerous biological activities in which anticancer is important one …

Amino-4, 6-dimethylpyrazolopyridine was applied as a precursor for the synthesis of some
new pyridopyrazolo-triazine and pyridopyrazolo-triazole derivatives through diazotization …

Abstract The reaction of 3-amino-5-phenylaminopyrazoles 2 with 3-(dimethylamino)
acrylonitrile derivatives resulted in a series of substituted pyrazolopyrimidine analogues 4 …

Since VEGFR-2 plays a crucial role in tumor growth, angiogenesis, and metastasis, it is a
prospective target for cancer treatment. In this work, a series of 3-phenyl-4-(2-substituted …

A novel series of pyrazoles and pyrazolo [1, 5-a] pyrimidines bearing benzothiazole moiety
were designed and synthesized. Chemical structures were confirmed by spectral data and …