Abstract Serotonin (5‐hydroxytryptophan [5‐HT]) is a biologically active amine expressed in
platelets, in gastrointestinal (GI) cells and, to a lesser extent, in the central nervous system …

Abstract Hyperactivity of serotonin 3 receptors (5-HT3R) underlies pathologies associated
with irritable bowel syndrome and chemotherapy-induced nausea and vomiting. Setrons, a …

The nonapeptide hormone oxytocin (OT) has pivotal brain roles in social recognition and
interaction and is thus a promising therapeutic drug for social deficits. Because of its peptide …

Abstract The Department of Medicinal Chemistry, together with the Institute for Structural
Biology, Drug Discovery and Development, at Virginia Commonwealth University (VCU) has …

Aim: The σ1 receptor is a druggable target involved in many physiological processes and
diseases. To clarify its physiology and derive therapeutic benefit, nine analogs based on the …

We previously reported that N-(3-chlorophenyl) guanidine (1) represents a novel α7 nicotinic
ACh (nACh) receptor antagonist chemotype. In the present study, a small series of …

Depression astonishingly can be stopped instantly by electrotherapies or through some
psychedelics like psilocybin. In explaining this, the traditional approaches to their …

Arylguanidines, depending upon their aromatic substitution pattern, display varying actions
at 5-HT3 receptors (eg, partial agonist, agonist, superagonist). Here, we demonstrate that …

Abstract meta-Chlorophenylguanidine (1) is a non-competitive α7 nicotinic acetylcholine
receptor (nAChR) antagonist. Here we examined the hydrogen bond donor role of the …

Peptide-receptor radionuclide therapy (PRRT) is a modality of molecular radiotherapy in
which patients are administered with radiolabelled peptides targeting peptide-receptors …