The relationships between inflammation and cancer are varied and complex. An important
connection linking inflammation to cancer development is DNA damage. During …

Cancer initiating/stem cells (CSCs) undergo self-renewal and differentiation that contributes
to tumor initiation, recurrence and metastasis in colorectal cancer (CRC). Targeting of …

Purpose Preclinical studies using ultra-high dose rate (FLASH) irradiation have
demonstrated reduced normal tissue toxicity compared with conventional dose rate (CONV) …

Ionizing radiation (IR) dose, dose rate, and linear energy transfer (LET) determine cellular
DNA damage quality and quantity. High-LET heavy ions are prevalent in the deep space …

Proliferative gastrointestinal (GI) tissue is radiation-sensitive, and heavy-ion space radiation
with its high-linear energy transfer (high-LET) and higher damaging potential than low-LET γ …

Therapy-induced senescence (TIS) is a major cellular response to anticancer therapies.
While induction of a persistent growth arrest would be a desirable outcome in cancer …

Colon cancer is a multifactorial disease associated with a variety of lifestyle factors.
Alterations in the gut microbiota and the intestinal metabolome are noted during colon …

Heavy ion radiation, prevalent in outer space and relevant for radiotherapy, is densely
ionizing and poses risk to stem cells that are key to intestinal homeostasis. Currently, the …

Current 3D culture models to study colorectal cancer lack architectural support and signaling
proteins provided by the tissue extracellular matrix (ECM) which may influence cell behavior …

Conventional and targeted cancer therapies may induce a cellular senescence program
termed therapy-induced senescence. However, unlike normal cells, cancer cells are able to …