Recent advances in single-cell technologies have enabled high-throughput molecular
profiling of cells across modalities and locations. Single-cell transcriptomics data can now …

Methods for profiling RNA and protein expression in a spatially resolved manner are rapidly
evolving, making it possible to comprehensively characterize cells and tissues in health and …

The function of many biological systems, such as embryos, liver lobules, intestinal villi, and
tumors, depends on the spatial organization of their cells. In the past decade, high …

Understanding intratumoral heterogeneity—the molecular variation among cells within a
tumor—promises to address outstanding questions in cancer biology and improve the …

Spatial omics data are advancing the study of tissue organization and cellular
communication at an unprecedented scale. Flexible tools are required to store, integrate and …

Spatial transcriptomics is a rapidly growing field that promises to comprehensively
characterize tissue organization and architecture at the single-cell or subcellular resolution …

Spatially resolved omics technologies are transforming our understanding of biological
tissues. However, the handling of uni-and multimodal spatial omics datasets remains a …

Multiplexed imaging enables the simultaneous spatial profiling of dozens of biological
molecules in tissues at single-cell resolution. Extracting biologically relevant information …

Abstract Interleukin (IL)-26 is a TH17 cytokine with known antimicrobial and pro-
inflammatory functions. However, the precise role of IL-26 in the context of pathogenic TH17 …

Spatial proteomics technologies have revealed an underappreciated link between the
location of cells in tissue microenvironments and the underlying biology and clinical …