The gut microbiome as a modulator of healthy ageing

TS Ghosh, F Shanahan, PW O'Toole - … Reviews Gastroenterology & …, 2022‏ - nature.com
The gut microbiome is a contributory factor in ageing-related health loss and in several non-
communicable diseases in all age groups. Some age-linked and disease-linked …

[HTML][HTML] Autophagy in inflammation, infection, and immunometabolism

V Deretic - Immunity, 2021‏ - cell.com
Autophagy is a quality-control, metabolic, and innate immunity process. Normative
autophagy affects many cell types, including hematopoietic as well as non-hematopoietic …

The molecular epidemiology of multiple zoonotic origins of SARS-CoV-2

JE Pekar, A Magee, E Parker, N Moshiri, K Izhikevich… - Science, 2022‏ - science.org
Understanding the circumstances that lead to pandemics is important for their prevention.
We analyzed the genomic diversity of severe acute respiratory syndrome coronavirus 2 …

Multicenter epidemiologic study of coronavirus disease–associated mucormycosis, India

A Patel, R Agarwal, SM Rudramurthy… - Emerging infectious …, 2021‏ - pmc.ncbi.nlm.nih.gov
During September–December 2020, we conducted a multicenter retrospective study across
India to evaluate epidemiology and outcomes among cases of coronavirus disease (COVID …

Coronavirus biology and replication: implications for SARS-CoV-2

P V'kovski, A Kratzel, S Steiner, H Stalder… - Nature Reviews …, 2021‏ - nature.com
The SARS-CoV-2 pandemic and its unprecedented global societal and economic disruptive
impact has marked the third zoonotic introduction of a highly pathogenic coronavirus into the …

Virus-induced senescence is a driver and therapeutic target in COVID-19

S Lee, Y Yu, J Trimpert, F Benthani, M Mairhofer… - Nature, 2021‏ - nature.com
Derailed cytokine and immune cell networks account for the organ damage and the clinical
severity of COVID-19 (refs.,,–). Here we show that SARS-CoV-2, like other viruses, evokes …

Predictors of COVID‐19 severity: a literature review

B Gallo Marin, G Aghagoli, K Lavine… - Reviews in medical …, 2021‏ - Wiley Online Library
Summary The coronavirus disease 2019 (COVID‐19) pandemic is a rapidly evolving global
emergency that continues to strain healthcare systems. Emerging research describes a …

Association of cardiac infection with SARS-CoV-2 in confirmed COVID-19 autopsy cases

D Lindner, A Fitzek, H Bräuninger… - JAMA …, 2020‏ - jamanetwork.com
Importance Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can be
documented in various tissues, but the frequency of cardiac involvement as well as possible …

An inflammatory cytokine signature predicts COVID-19 severity and survival

DM Del Valle, S Kim-Schulze, HH Huang… - Nature medicine, 2020‏ - nature.com
Several studies have revealed that the hyper-inflammatory response induced by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a major cause of disease …

The immunology of multisystem inflammatory syndrome in children with COVID-19

CR Consiglio, N Cotugno, F Sardh, C Pou, D Amodio… - Cell, 2020‏ - cell.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is typically very
mild and often asymptomatic in children. A complication is the rare multisystem inflammatory …