Therapeutic potential of nucleic acid‐binding isoquinoline alkaloids: Binding aspects and implications for drug design
Isoquinoline alkaloids represent a group of natural products with remarkable importance in
the contemporary biomedical research and drug discovery programs. Several members of …
the contemporary biomedical research and drug discovery programs. Several members of …
Molecular aspects on the interaction of protoberberine, benzophenanthridine, and aristolochia group of alkaloids with nucleic acid structures and biological …
M Maiti, GS Kumar - Medicinal Research Reviews, 2007 - Wiley Online Library
Alkaloids occupy an important position in chemistry and pharmacology. Among the various
alkaloids, berberine and coralyne of the protoberberine group, sanguinarine of the …
alkaloids, berberine and coralyne of the protoberberine group, sanguinarine of the …
Groove binding mechanism of ionic liquids: a key factor in long-term stability of DNA in hydrated ionic liquids?
A Chandran, D Ghoshdastidar… - Journal of the American …, 2012 - ACS Publications
Nucleic acid sample storage is of paramount importance in biotechnology and forensic
sciences. Very recently, hydrated ionic liquids (ILs) have been identified as ideal media for …
sciences. Very recently, hydrated ionic liquids (ILs) have been identified as ideal media for …
[PDF][PDF] Mechanism of DNA binding and cleavage
The necessity for cellular regulation of DNA led to the development of metallonucleases to
catalyze and repair DNA strand breaks. Due to cationic character, three-dimensional …
catalyze and repair DNA strand breaks. Due to cationic character, three-dimensional …
Molecular aspects on the interaction of phenosafranine to deoxyribonucleic acid: Model for intercalative drug–DNA binding
The mode, mechanism and energetics of interaction of phenosafranine, the planar, cationic
and rigid phenazium dye to calf thymus DNA was investigated from absorption …
and rigid phenazium dye to calf thymus DNA was investigated from absorption …
Chitosan-based dithiophenolato nanoparticles: Preparation, mechanistic information of DNA binding, antibacterial and cytotoxic activities
The work aimed to synthesize the chitosan-based dithiophenolato nanoparticles (DTP-CS
NPs), evaluate in-vitro DNA-binding mechanistically in detail, correlate the results with …
NPs), evaluate in-vitro DNA-binding mechanistically in detail, correlate the results with …
Spectroscopic and calorimetric studies on the binding of alkaloids berberine, palmatine and coralyne to double stranded RNA polynucleotides
MM Islam, SR Chowdhury… - The Journal of Physical …, 2009 - ACS Publications
The interaction of two natural protoberberine plant alkaloids berberine and palmatine and a
synthetic derivative coralyne to three double stranded ribonucleic acids, poly (A). poly (U) …
synthetic derivative coralyne to three double stranded ribonucleic acids, poly (A). poly (U) …
Design, DNA binding and kinetic studies, antibacterial and cytotoxic activities of stable dithiophenolato titanium (IV)-chitosan Nanocomposite
NZ Shaban, SA Yehia, KR Shoueir, SR Saleh… - Journal of Molecular …, 2019 - Elsevier
Highly thermal stable dithiophenolato Ti (IV)-chitosan nanocomposite (DBT-CS) was formed
from dithiophenolato Ti (IV)-complex (DBT) and chitosan (CS) nanoparticles. As DNA-drugs …
from dithiophenolato Ti (IV)-complex (DBT) and chitosan (CS) nanoparticles. As DNA-drugs …
Enhanced killing of intracellular multidrug-resistant Mycobacterium tuberculosis by compounds that affect the activity of efflux pumps
Whereas human neutrophils are effective and efficient killers of bacteria, macrophages such
as those derived from monocytes are almost devoid of killing activity. Nevertheless …
as those derived from monocytes are almost devoid of killing activity. Nevertheless …
Interaction of Isoquinoline Alkaloids with an RNA Triplex: Structural and Thermodynamic Studies of Berberine, Palmatine, and Coralyne Binding to Poly(U).Poly(A)* …
R Sinha, GS Kumar - The Journal of Physical Chemistry B, 2009 - ACS Publications
The interaction of two natural protoberberine alkaloids berberine and palmatine and the
synthetic derivative coralyne with the RNA triplex poly (U). poly (A)* poly (U) was studied …
synthetic derivative coralyne with the RNA triplex poly (U). poly (A)* poly (U) was studied …