Biological processes are regulated by intermolecular interactions and chemical
modifications that do not affect protein levels, thus esca** detection in classical proteomic …

Life is resilient because living systems are able to respond to elevated temperatures with an
ancient gene expression program called the heat shock response (HSR). In yeast, the …

From biosynthesis to assembly into nucleosomes, histones are handed through a cascade
of histone chaperones, which shield histones from non-specific interactions. Whether …

Maintenance of cellular proteostasis is achieved by a multi-layered quality control network,
which counteracts the accumulation of misfolded proteins by refolding and degradation …

Cells respond to stress by synthesizing chaperone proteins that seek to correct protein
misfolding and maintain function. However, abrogation of protein homeostasis is a hallmark …

Chaperones are a highly interactive group of proteins that function globally in many cellular
processes involved in maintaining protein homeostasis. Traditional biochemical assays …

Background Protein content determines the state of cells. The variation in protein
abundance is crucial when organisms are in the early stages of heat stress, but the reasons …

Translation initiation factor 4G (eIF4G) is an integral component of the eIF4F complex which
is key to translation initiation for most eukaryotic mRNAs. Many eIF4G isoforms have been …

Dietary restriction (DR) has been shown to increase lifespan in organisms ranging from
yeast to mammals. This suggests that the underlying mechanisms may be evolutionarily …

Eukaryotic cells respond to heat shock through several regulatory processes including
upregulation of stress responsive chaperones and reversible shutdown of cellular activities …