The effects of temperature on aerobic metabolism: towards a mechanistic understanding of the responses of ectotherms to a changing environment

PM Schulte - The Journal of experimental biology, 2015 - journals.biologists.com
Because of its profound effects on the rates of biological processes such as aerobic
metabolism, environmental temperature plays an important role in sha** the distribution …

Modifying yeast tolerance to inhibitory conditions of ethanol production processes

L Caspeta, T Castillo, J Nielsen - Frontiers in Bioengineering and …, 2015 - frontiersin.org
Saccharomyces cerevisiae strains having a broad range of substrate utilization, rapid
substrate consumption, and conversion to ethanol, as well as good tolerance to inhibitory …

Transcriptional regulation is insufficient to explain substrate‐induced flux changes in Bacillus subtilis

V Chubukov, M Uhr, L Le Chat, RJ Kleijn… - Molecular systems …, 2013 - embopress.org
One of the key ways in which microbes are thought to regulate their metabolism is by
modulating the availability of enzymes through transcriptional regulation. However, the …

Simultaneous nanorheometry and nanothermometry using intracellular diamond quantum sensors

Q Gu, L Shanahan, JW Hart, S Belser, N Shofer… - ACS …, 2023 - ACS Publications
The viscoelasticity of the cytoplasm plays a critical role in cell morphology, cell division, and
intracellular transport. Viscoelasticity is also interconnected with other biophysical …

Yeasts collectively extend the limits of habitable temperatures by secreting glutathione

DS Laman Trip, H Youk - Nature microbiology, 2020 - nature.com
The conventional view is that high temperatures cause microorganisms to replicate slowly or
die. In this view, microorganisms autonomously combat heat-induced damages. However …

Genome-wide analysis of yeast stress survival and tolerance acquisition to analyze the central trade-off between growth rate and cellular robustness

A Zakrzewska, G Van Eikenhorst… - Molecular biology of …, 2011 - Am Soc Cell Biol
All organisms have evolved to cope with changes in environmental conditions, ensuring the
optimal combination of proliferation and survival. In yeast, exposure to a mild stress leads to …

Yeast increases glycolytic flux to support higher growth rates accompanied by decreased metabolite regulation and lower protein phosphorylation

M Chen, T **e, H Li, Y Zhuang… - Proceedings of the …, 2023 - National Acad Sciences
Supply of Gibbs free energy and precursors are vital for cellular function and cell metabolism
have evolved to be tightly regulated to balance their supply and consumption. Precursors …

Measuring enzyme activities under standardized in vivo‐like conditions for systems biology

K Van Eunen, J Bouwman, P Daran‐Lapujade… - The FEBS …, 2010 - Wiley Online Library
Realistic quantitative models require data from many laboratories. Therefore,
standardization of experimental systems and assay conditions is crucial. Moreover …

Bayesian genome scale modelling identifies thermal determinants of yeast metabolism

G Li, Y Hu, J Zrimec, H Luo, H Wang… - Nature …, 2021 - nature.com
The molecular basis of how temperature affects cell metabolism has been a long-standing
question in biology, where the main obstacles are the lack of high-quality data and methods …

Bioenergetic pathways in tumor mitochondria as targets for cancer therapy and the importance of the ROS-induced apoptotic trigger

SJ Ralph, S Rodríguez-Enríquez, J Neuzil… - Molecular aspects of …, 2010 - Elsevier
Mitochondria are emerging as idealized targets for anti-cancer drugs. One reason for this is
that although these organelles are inherent to all cells, drugs are being developed that …