Breast cancer's tendency to metastasize poses a critical barrier to effective treatment,
making it a leading cause of mortality among women worldwide. A growing body of …

Elevated mammalian target of rapamycin (mTOR) signaling has been found in Alzheimer's
disease (AD) patients and is linked to diabetes and aging, two known risk factors for AD …

Breast cancer is the most frequent female malignancy worldwide. Current strategies in
breast cancer therapy, including classical chemotherapy, hormone therapy, and targeted …

Poor patient response and limited treatment modalities are the major challenges against
combating triple-negative breast cancer (TNBC). The high related mortality urges for novel …

Cells employ several adaptive mechanisms under conditions of accelerated cell division,
such as the unfolded protein response (UPR). The UPR is composed of a tripartite signaling …

The mTOR nucleates two complexes, namely mTOR complex 1 and 2 (mTORC1 and
mTORC2), which are implicated in cell growth, survival, metabolism, and cancer …

Objective This study aims to investigate the effects of endoplasmic reticulum stress (ERS) on
autophagy, apoptosis and chemoresistance of human small cell lung cancer (SCLC) cells …

The metabolic steroid hormones, 17β stradiol (E2) and testosterone play key roles in several
functions including carbohydrate, lipid and protein metabolism, cellular signaling, cell …

Inhibitors of poly [ADP-ribose] polymerase 1 (PARPis) show promise for treatment of cancers
which lack capacity for homologous recombination repair (HRR). However, new therapeutic …

We found that pediatric glioblastoma (PED-GBM) cell lines from diffuse intrinsic pontine
glioma (DIPG) carrying the H3K27M mutation or from diffuse hemispheric glioma expressing …