The develo** human brain displays unique features that are difficult to study in animal
models. Current in vitro models based on human brain tissue face several challenges …

Some cancers such as glioblastoma (GBM), show minimal response to medical
interventions, often only capable of mitigating tumor growth or alleviating symptoms. High …

Recent advances in cancer biology and therapeutics have underscored the importance of
preclinical models in understanding and treating cancer. Nevertheless, current models often …

Human organoids are a widely used tool in cell biology to study homeostatic processes,
disease, and development. The term organoids covers a plethora of model systems from …

Glioblastoma (GBM) is a highly aggressive adult brain cancer, characterised by poor
prognosis and a dismal five-year survival rate. Despite significant knowledge gains in …

Glioblastoma (GBM) is a relatively rare but highly aggressive form of brain cancer
characterized by rapid growth, invasiveness, and resistance to standard therapies. Despite …

Understanding the molecular and cellular mechanisms driving pediatric low-grade glioma
(pLGG)—the most prevalent brain tumor in children—is essential for the identification and …

Background Tumorigenicity represents a critical challenge in stem cell-based therapies
requiring rigorous monitoring. Conventional approaches for tumorigenicity evaluation are …

Reduced therapy response in breast cancer has been correlated with heterogeneity in
biomarker composition, expression level, and spatial distribution of cancer cells within a …

Osimertinib resistance remains a significant challenge in the treatment of non‐small cell
lung cancer (NSCLC). N6‐methyladenosine (m6A) modifications are closely linked to …