Accurate structure prediction of biomolecular interactions with AlphaFold 3
The introduction of AlphaFold 21 has spurred a revolution in modelling the structure of
proteins and their interactions, enabling a huge range of applications in protein modelling …
proteins and their interactions, enabling a huge range of applications in protein modelling …
Drug tolerant persister cell plasticity in cancer: A revolutionary strategy for more effective anticancer therapies
J He, Z Qiu, J Fan, X **e, Q Sheng, X Sui - Signal transduction and …, 2024 - nature.com
Non-genetic mechanisms have recently emerged as important drivers of anticancer drug
resistance. Among these, the drug tolerant persister (DTP) cell phenotype is attracting more …
resistance. Among these, the drug tolerant persister (DTP) cell phenotype is attracting more …
Protein lipidation in cancer: mechanisms, dysregulation and emerging drug targets
Protein lipidation describes a diverse class of post-translational modifications (PTMs) that is
regulated by over 40 enzymes, targeting more than 1,000 substrates at over 3,000 sites …
regulated by over 40 enzymes, targeting more than 1,000 substrates at over 3,000 sites …
Lipid droplets sequester palmitic acid to disrupt endothelial ciliation and exacerbate atherosclerosis in male mice
Y Tan, Z Huang, Y **, J Wang, H Fan, Y Liu… - Nature …, 2024 - nature.com
Disruption of ciliary homeostasis in vascular endothelial cells has been implicated in the
development of atherosclerosis. However, the molecular basis for the regulation of …
development of atherosclerosis. However, the molecular basis for the regulation of …
The structure of phosphatidylinositol remodeling MBOAT7 reveals its catalytic mechanism and enables inhibitor identification
Cells remodel glycerophospholipid acyl chains via the Lands cycle to adjust membrane
properties. Membrane-bound O-acyltransferase (MBOAT) 7 acylates lyso …
properties. Membrane-bound O-acyltransferase (MBOAT) 7 acylates lyso …
Cryo-EM structures of Myomaker reveal a molecular basis for myoblast fusion
T Long, Y Zhang, L Donnelly, H Li, YC Pien… - Nature Structural & …, 2023 - nature.com
The fusion of mononucleated myoblasts produces multinucleated muscle fibers leading to
the formation of skeletal muscle. Myomaker, a skeletal muscle-specific membrane protein, is …
the formation of skeletal muscle. Myomaker, a skeletal muscle-specific membrane protein, is …
Molecular mechanism of palmitic acid and its derivatives in tumor progression
X Wang, C Zhang, N Bao - Frontiers in oncology, 2023 - frontiersin.org
Palmitic acid (PA) is a saturated fatty acid commonly found in coconut oil and palm oil. It
serves as an energy source for the body and plays a role in the structure and function of cell …
serves as an energy source for the body and plays a role in the structure and function of cell …
Rocking the MBOAT: Structural insights into the membrane bound O-acyltransferase family
CE Coupland, TB Ansell, MSP Sansom… - Current Opinion in …, 2023 - Elsevier
The membrane-bound O-acyltransferase (MBOAT) superfamily catalyses the transfer of acyl
chains to substrates implicated in essential cellular functions. Aberrant function of MBOATs …
chains to substrates implicated in essential cellular functions. Aberrant function of MBOATs …
Structure and mechanism of lysosome transmembrane acetylation by HGSNAT
R Xu, Y Ning, F Ren, C Gu, Z Zhu, X Pan… - Nature Structural & …, 2024 - nature.com
Lysosomal transmembrane acetylation of heparan sulfates (HS) is catalyzed by HS acetyl-
CoA: α-glucosaminide N-acetyltransferase (HGSNAT), whose dysfunction leads to …
CoA: α-glucosaminide N-acetyltransferase (HGSNAT), whose dysfunction leads to …
Beyond energy and growth: the role of metabolism in developmental signaling, cell behavior and diapause
Metabolism is crucial for development through supporting cell growth, energy production,
establishing cell identity, developmental signaling and pattern formation. In many model …
establishing cell identity, developmental signaling and pattern formation. In many model …