Molecular biology, epidemiology, and pathogenesis of progressive multifocal leukoencephalopathy, the JC virus-induced demyelinating disease of the human brain
Progressive multifocal leukoencephalopathy (PML) is a debilitating and frequently fatal
central nervous system (CNS) demyelinating disease caused by JC virus (JCV), for which …
central nervous system (CNS) demyelinating disease caused by JC virus (JCV), for which …
The DNA replication fork in eukaryotic cells
S Waga, B Stillman - Annual review of biochemistry, 1998 - annualreviews.org
Replication of the two template strands at eukaryotic cell DNA replication forks is a highly
coordinated process that ensures accurate and efficient genome duplication. Biochemical …
coordinated process that ensures accurate and efficient genome duplication. Biochemical …
The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA
THE p53 tumour-suppressor protein controls the expression of a gene encoding the p21
cyclin-dependent protein kinase (CDK) regulator1–6. Levels of p21 protein are increased in …
cyclin-dependent protein kinase (CDK) regulator1–6. Levels of p21 protein are increased in …
Replication-dependent marking of DNA by PCNA facilitates CAF-1-coupled inheritance of chromatin
K Shibahara, B Stillman - Cell, 1999 - cell.com
Abstract Chromatin assembly factor 1 (CAF-1) is required for inheritance of epigenetically
determined chromosomal states in vivo and promotes assembly of chromatin during DNA …
determined chromosomal states in vivo and promotes assembly of chromatin during DNA …
[HTML][HTML] Recombinant replication protein A: expression, complex formation, and functional characterization
LA Henricksen, CB Umbricht, MS Wold - Journal of Biological Chemistry, 1994 - Elsevier
Replication protein A (RPA) is a multisubunit, single-stranded DNA-binding protein that is
absolutely required for replication of SV40 DNA. The three cDNAs encoding the subunits of …
absolutely required for replication of SV40 DNA. The three cDNAs encoding the subunits of …
A major role of DNA polymerase δ in replication of both the leading and lagging DNA strands
RE Johnson, R Klassen, L Prakash, S Prakash - Molecular cell, 2015 - cell.com
Genetic studies with S. cerevisiae Polδ (pol3-L612M) and Polε (pol2-M644G) mutant alleles,
each of which display a higher rate for the generation of a specific mismatch, have led to the …
each of which display a higher rate for the generation of a specific mismatch, have led to the …
Mechanism of action of hydroxyurea.
JW Yarbro - Seminars in oncology, 1992 - europepmc.org
Hydroxyurea is well absorbed after oral administration, converted to a free radical nitroxide
in vivo, and transported by diffusion into cells where it quenches the tyrosyl free radical at …
in vivo, and transported by diffusion into cells where it quenches the tyrosyl free radical at …
Proliferating cell nuclear antigen is required for DNA excision repair
MKK Shivji, MK Kenny, RD Wood - Cell, 1992 - cell.com
Fractionation of extracts from human cell lines allows nucleotide excision repair of damaged
DNA to be resolved into discrete incision and polymerization stages. Generation of incised …
DNA to be resolved into discrete incision and polymerization stages. Generation of incised …
DNA primases
DN Frick, CC Richardson - Annual review of biochemistry, 2001 - annualreviews.org
▪ Abstract DNA primases are enzymes whose continual activity is required at the DNA
replication fork. They catalyze the synthesis of short RNA molecules used as primers for …
replication fork. They catalyze the synthesis of short RNA molecules used as primers for …
Anatomy of a DNA replication fork revealed by reconstitution of SV40 DNA replication in vitro
S Waga, B Stillman - Nature, 1994 - nature.com
Complete enzymatic replication of DNA from the simian virus 40 origin has been
reconstituted with T antigen and highly purified cellular proteins. DNA polymerase-α/primase …
reconstituted with T antigen and highly purified cellular proteins. DNA polymerase-α/primase …