In the 12 years since the publication of the first Consensus Paper of the WFSBP on
biomarkers of neurodegenerative dementias, enormous advancement has taken place in …

Alzheimer's disease pathology is closely connected to the processing of the amyloid
precursor protein (APP) resulting in the formation of a variety of amyloid-beta (Aβ) peptides …

β-Amyloid (Aβ) peptides are thought to be critically involved in the etiology of Alzheimer's
disease (AD). The aspartyl protease β-site amyloid precursor protein cleaving enzyme 1 …

The beta‐site amyloid precursor protein cleaving enzyme‐1 (BACE‐1) initiates the
generation of amyloid‐β (Aβ), and the amyloid cascade leading to amyloid plaque …

Abstract Treatment of Alzheimer's disease (AD) is significantly hampered by the lack of
easily accessible biomarkers that can detect disease presence and predict disease risk …

Reduced cerebrospinal fluid amyloid-β42 and increased retention of florbetapir positron
emission tomography are biomarkers reflecting cortical amyloid load in Alzheimer's disease …

Neurodegenerative diseases present a major and increasing burden in the societies
worldwide. With aging populations, the prevalence of neurodegenerative diseases is …

Alzheimer disease (AD) and Parkinson disease (PD) are the most common
neurodegenerative disorders. For both diseases, early intervention is thought to be essential …

Neuroinflammatory and neurodegenerative diseases are characterized by the interplay of a
number of molecular pathways that can be assessed through biofluids, especially …

The histopathology of Alzheimer's disease (AD) is characterized by neuronal loss,
neurofibrillary tangles, and senile plaque formation. The latter results from an exacerbated …