[HTML][HTML] Genetic insights into the neurobiology of anxiety

MK Koskinen, I Hovatta - Trends in Neurosciences, 2023 - cell.com
Anxiety and fear are evolutionarily conserved emotions that increase the likelihood of an
organism surviving threatening situations. Anxiety and vigilance states are regulated by …

A compendium of genetic regulatory effects across pig tissues

J Teng, Y Gao, H Yin, Z Bai, S Liu, H Zeng… - Nature …, 2024 - nature.com
Abstract The Farm Animal Genotype-Tissue Expression (FarmGTEx) project has been
established to develop a public resource of genetic regulatory variants in livestock, which is …

Single-nucleus genomics in outbred rats with divergent cocaine addiction-like behaviors reveals changes in amygdala GABAergic inhibition

JL Zhou, G de Guglielmo, AJ Ho, M Kallupi… - Nature …, 2023 - nature.com
The amygdala processes positive and negative valence and contributes to addiction, but the
cell-type-specific gene regulatory programs involved are unknown. We generated an atlas of …

Comparative Genomics and Epigenomics of Transcriptional Regulation

H Zhou, E Clark, D Guan, S Lagarrigue… - Annual review of …, 2024 - annualreviews.org
Transcriptional regulation in response to diverse physiological cues involves complicated
biological processes. Recent initiatives that leverage whole genome sequencing and …

[HTML][HTML] Genome-wide association studies of human and rat BMI converge on synapse, epigenome, and hormone signaling networks

SN Wright, BS Leger, SB Rosenthal, SN Liu, T Jia… - Cell reports, 2023 - cell.com
A vexing observation in genome-wide association studies (GWASs) is that parallel analyses
in different species may not identify orthologous genes. Here, we demonstrate that cross …

[HTML][HTML] A revamped rat reference genome improves the discovery of genetic diversity in laboratory rats

TV de Jong, Y Pan, P Rastas, D Munro, M Tutaj, H Akil… - Cell Genomics, 2024 - cell.com
The seventh iteration of the reference genome assembly for Rattus norvegicus—mRatBN7.
2—corrects numerous misplaced segments and reduces base-level errors by approximately …

Gene expression variation underlying tissue-specific responses to copper stress in Drosophila melanogaster

ER Everman, SJ Macdonald - G3: Genes, Genomes, Genetics, 2024 - academic.oup.com
Copper is one of a handful of biologically necessary heavy metals that is also a common
environmental pollutant. Under normal conditions, copper ions are required for many key …

A “Four Core Genotypes” rat model to distinguish mechanisms underlying sex-biased phenotypes and diseases

AP Arnold, X Chen, MN Grzybowski, JM Ryan… - bioRxiv, 2023 - biorxiv.org
Background We have generated a rat model similar to the Four Core Genotypes mouse
model, allowing comparison of XX and XY rats with the same type of gonad. The model …

Standardized pipelines support and facilitate integration of diverse datasets at the Rat Genome Database

JR Smith, MA Tutaj, J Thota, L Lamers, AC Gibson… - Database, 2025 - academic.oup.com
Abstract The Rat Genome Database (RGD) is a multispecies knowledgebase which
integrates genetic, multiomic, phenotypic, and disease data across 10 mammalian species …

Gene expression genetics of the striatum of Diversity Outbred mice

VM Philip, H He, MC Saul, PE Dickson, JA Bubier… - Scientific Data, 2023 - nature.com
Brain transcriptional variation is a heritable trait that mediates complex behaviors, including
addiction. Expression quantitative trait locus (eQTL) map** reveals genomic regions …