[HTML][HTML] Genetic insights into the neurobiology of anxiety
MK Koskinen, I Hovatta - Trends in Neurosciences, 2023 - cell.com
Anxiety and fear are evolutionarily conserved emotions that increase the likelihood of an
organism surviving threatening situations. Anxiety and vigilance states are regulated by …
organism surviving threatening situations. Anxiety and vigilance states are regulated by …
A compendium of genetic regulatory effects across pig tissues
Abstract The Farm Animal Genotype-Tissue Expression (FarmGTEx) project has been
established to develop a public resource of genetic regulatory variants in livestock, which is …
established to develop a public resource of genetic regulatory variants in livestock, which is …
Single-nucleus genomics in outbred rats with divergent cocaine addiction-like behaviors reveals changes in amygdala GABAergic inhibition
The amygdala processes positive and negative valence and contributes to addiction, but the
cell-type-specific gene regulatory programs involved are unknown. We generated an atlas of …
cell-type-specific gene regulatory programs involved are unknown. We generated an atlas of …
Comparative Genomics and Epigenomics of Transcriptional Regulation
Transcriptional regulation in response to diverse physiological cues involves complicated
biological processes. Recent initiatives that leverage whole genome sequencing and …
biological processes. Recent initiatives that leverage whole genome sequencing and …
[HTML][HTML] Genome-wide association studies of human and rat BMI converge on synapse, epigenome, and hormone signaling networks
A vexing observation in genome-wide association studies (GWASs) is that parallel analyses
in different species may not identify orthologous genes. Here, we demonstrate that cross …
in different species may not identify orthologous genes. Here, we demonstrate that cross …
[HTML][HTML] A revamped rat reference genome improves the discovery of genetic diversity in laboratory rats
The seventh iteration of the reference genome assembly for Rattus norvegicus—mRatBN7.
2—corrects numerous misplaced segments and reduces base-level errors by approximately …
2—corrects numerous misplaced segments and reduces base-level errors by approximately …
Gene expression variation underlying tissue-specific responses to copper stress in Drosophila melanogaster
ER Everman, SJ Macdonald - G3: Genes, Genomes, Genetics, 2024 - academic.oup.com
Copper is one of a handful of biologically necessary heavy metals that is also a common
environmental pollutant. Under normal conditions, copper ions are required for many key …
environmental pollutant. Under normal conditions, copper ions are required for many key …
A “Four Core Genotypes” rat model to distinguish mechanisms underlying sex-biased phenotypes and diseases
Background We have generated a rat model similar to the Four Core Genotypes mouse
model, allowing comparison of XX and XY rats with the same type of gonad. The model …
model, allowing comparison of XX and XY rats with the same type of gonad. The model …
Standardized pipelines support and facilitate integration of diverse datasets at the Rat Genome Database
JR Smith, MA Tutaj, J Thota, L Lamers, AC Gibson… - Database, 2025 - academic.oup.com
Abstract The Rat Genome Database (RGD) is a multispecies knowledgebase which
integrates genetic, multiomic, phenotypic, and disease data across 10 mammalian species …
integrates genetic, multiomic, phenotypic, and disease data across 10 mammalian species …
Gene expression genetics of the striatum of Diversity Outbred mice
Brain transcriptional variation is a heritable trait that mediates complex behaviors, including
addiction. Expression quantitative trait locus (eQTL) map** reveals genomic regions …
addiction. Expression quantitative trait locus (eQTL) map** reveals genomic regions …