Chiral photocatalyst structures in asymmetric photochemical synthesis

MJ Genzink, JB Kidd, WB Swords, TP Yoon - Chemical reviews, 2021 - ACS Publications
Asymmetric catalysis is a major theme of research in contemporary synthetic organic
chemistry. The discovery of general strategies for highly enantioselective photochemical …

Bimetallic catalysis in stereodivergent synthesis

X Huo, G Li, X Wang, W Zhang - Angewandte Chemie, 2022 - Wiley Online Library
Bimetallic catalysis has emerged as an efficient strategy for the development of new
chemical reactions. Importantly, this strategy also provides a simple and powerful platform …

Enantioconvergent Cu-catalysed N-alkylation of aliphatic amines

JJ Chen, JH Fang, XY Du, JY Zhang, JQ Bian, FL Wang… - Nature, 2023 - nature.com
Chiral amines are commonly used in the pharmaceutical and agrochemical industries. The
strong demand for unnatural chiral amines has driven the development of catalytic …

Synergistic dual catalysis in stereodivergent synthesis

L Wei, C Fu, ZF Wang, HY Tao, CJ Wang - ACS Catalysis, 2024 - ACS Publications
Chiral skeletons with multiple stereogenic centers widely reside in nature and drugs, and
their relative and absolute configuration often determine their physiological or …

Alcohols as substrates in transition-metal-catalyzed arylation, alkylation, and related reactions

A Cook, SG Newman - Chemical Reviews, 2024 - ACS Publications
Alcohols are abundant and attractive feedstock molecules for organic synthesis. Many
methods for their functionalization require them to first be converted into a more activated …

Ligand development for copper-catalyzed enantioconvergent radical cross-coupling of racemic alkyl halides

XY Dong, ZL Li, QS Gu, XY Liu - Journal of the American Chemical …, 2022 - ACS Publications
The enantioconvergent cross-coupling of racemic alkyl halides represents a powerful tool for
the synthesis of enantioenriched molecules. In this regard, the first-row transition metal …

Iridium-catalyzed asymmetric difunctionalization of C–C σ-bonds enabled by ring-strained boronate complexes

HC Shen, MV Popescu, ZS Wang… - Journal of the …, 2023 - ACS Publications
Enantioenriched organoboron intermediates are important building blocks in organic
synthesis and drug discovery. Recently, transition metal-catalyzed enantioselective 1, 2 …

Enantio‐and Diastereodivergent Synthesis of Spirocycles through Dual‐Metal‐Catalyzed [3+ 2] Annulation of 2‐Vinyloxiranes with Nucleophilic Dipoles

Y Peng, X Huo, Y Luo, L Wu, W Zhang - Angewandte Chemie, 2021 - Wiley Online Library
The development of efficient and straightforward methods for obtaining all optically active
isomers of structurally rigid spirocycles from readily available starting materials is of great …

Dispersion and steric effects on enantio-/diastereoselectivities in synergistic dual transition-metal catalysis

B Li, H Xu, Y Dang, KN Houk - Journal of the American Chemical …, 2022 - ACS Publications
Comprehensive computational studies were carried out to explore the mechanisms of
enantioselective Cu/Pd and stereodivergent Cu/Ir dual-catalytic syntheses of α, α …

Gold-catalyzed synthesis of small rings

M Mato, A Franchino, C Garcı́a-Morales… - Chemical …, 2020 - ACS Publications
Three-and four-membered rings, widespread motifs in nature and medicinal chemistry, have
fascinated chemists ever since their discovery. However, due to energetic considerations …