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Calprotectin: from biomarker to biological function
The incidence of inflammatory bowel diseases (IBD) emerged with Westernisation of dietary
habits worldwide. Crohn's disease and ulcerative colitis are chronic debilitating conditions …
habits worldwide. Crohn's disease and ulcerative colitis are chronic debilitating conditions …
S100A8 and S100A9 in Cancer
Abstract S100A8 and S100A9 are Ca 2+ binding proteins that belong to the S100 family.
Primarily expressed in neutrophils and monocytes, S100A8 and S100A9 play critical roles in …
Primarily expressed in neutrophils and monocytes, S100A8 and S100A9 play critical roles in …
S100A8/A9 in Inflammation
S Wang, R Song, Z Wang, Z **g, S Wang… - Frontiers in …, 2018 - frontiersin.org
S100A8 and S100A9 (also known as MRP8 and MRP14, respectively) are Ca2+ binding
proteins belonging to the S100 family. They often exist in the form of heterodimer, while …
proteins belonging to the S100 family. They often exist in the form of heterodimer, while …
S100A9-CXCL12 activation in BRCA1-mutant breast cancer promotes an immunosuppressive microenvironment associated with resistance to immunotherapy
Immune checkpoint blockade (ICB) is a powerful approach for cancer therapy although good
responses are only observed in a fraction of cancer patients. Breast cancers caused by …
responses are only observed in a fraction of cancer patients. Breast cancers caused by …
High level of neutrophil extracellular traps correlates with poor prognosis of severe influenza A infection
L Zhu, L Liu, Y Zhang, L Pu, J Liu, X Li… - The Journal of …, 2018 - academic.oup.com
Background Most patients with severe infection with influenza A virus (IAV) progress to acute
respiratory distress syndrome and even multiple organ dysfunction syndrome (MODS) …
respiratory distress syndrome and even multiple organ dysfunction syndrome (MODS) …
CXCR 4, the master regulator of neutrophil trafficking in homeostasis and disease
Background Chemokines play a critical role in orchestrating the distribution and trafficking of
neutrophils in homeostasis and disease. Results The CXCR 4/CXCL 12 chemokine axis has …
neutrophils in homeostasis and disease. Results The CXCR 4/CXCL 12 chemokine axis has …
Antimicrobial peptides: Defending the mucosal epithelial barrier
KF Johnstone, MC Herzberg - Frontiers in Oral Health, 2022 - frontiersin.org
The recent epidemic caused by aerosolized SARS-CoV-2 virus illustrates the importance
and vulnerability of the mucosal epithelial barrier against infection. Antimicrobial proteins …
and vulnerability of the mucosal epithelial barrier against infection. Antimicrobial proteins …
S100 family proteins in inflammation and beyond
The S100 family proteins possess a variety of intracellular and extracellular functions. They
interact with multiple receptors and signal transducers to regulate pathways that govern …
interact with multiple receptors and signal transducers to regulate pathways that govern …
Host-pathogen interactions in gram-positive bacterial pneumonia
Community-acquired pneumonia (CAP) is a leading cause of morbidity and mortality
worldwide. Despite broad literature including basic and translational scientific studies, many …
worldwide. Despite broad literature including basic and translational scientific studies, many …
S100A12 and the S100/calgranulins: emerging biomarkers for atherosclerosis and possibly therapeutic targets
Atherosclerosis is mediated by local and systematic inflammation. The multiligand receptor
for advanced glycation end products (RAGE) has been studied in animals and humans and …
for advanced glycation end products (RAGE) has been studied in animals and humans and …