Genetics of glaucoma
Genetic and genomic studies, including genome-wide association studies (GWAS) have
accelerated the discovery of genes contributing to glaucoma, the leading cause of …
accelerated the discovery of genes contributing to glaucoma, the leading cause of …
The genetic basis for adult onset glaucoma: recent advances and future directions
Glaucoma, a diverse group of eye disorders that results in the degeneration of retinal
ganglion cells, is the world's leading cause of irreversible blindness. Apart from age and …
ganglion cells, is the world's leading cause of irreversible blindness. Apart from age and …
Genome-wide association study identifies seven novel susceptibility loci for primary open-angle glaucoma
Primary open-angle glaucoma (POAG) is the leading cause of irreversible blindness
worldwide for which 15 disease-associated loci had been discovered. Among them, only 5 …
worldwide for which 15 disease-associated loci had been discovered. Among them, only 5 …
Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci
T Aung, M Ozaki, MC Lee, U Schlötzer-Schrehardt… - Nature …, 2017 - nature.com
Exfoliation syndrome (XFS) is the most common known risk factor for secondary glaucoma
and a major cause of blindness worldwide. Variants in two genes, LOXL1 and CACNA1A …
and a major cause of blindness worldwide. Variants in two genes, LOXL1 and CACNA1A …
Genome-wide association study identifies five new susceptibility loci for primary angle closure glaucoma
Primary angle closure glaucoma (PACG) is a major cause of blindness worldwide. We
conducted a genome-wide association study (GWAS) followed by replication in a combined …
conducted a genome-wide association study (GWAS) followed by replication in a combined …
Major review: exfoliation syndrome; advances in disease genetics, molecular biology, and epidemiology
Exfoliation syndrome (XFS) is a common age-related disorder that leads to deposition of
extracellular fibrillar material throughout the body. The most recognized disease …
extracellular fibrillar material throughout the body. The most recognized disease …
Molecular genetics of glaucoma: Subtype and ethnicity considerations
Glaucoma, the world's leading cause of irreversible blindness, is a complex disease, with
differential presentation as well as ethnic and geographic disparities. The multifactorial …
differential presentation as well as ethnic and geographic disparities. The multifactorial …
Differentially expressed microRNAs in the aqueous humor of patients with exfoliation glaucoma or primary open-angle glaucoma
MD Drewry, P Challa, JG Kuchtey… - Human molecular …, 2018 - academic.oup.com
Both exfoliation glaucoma (XFG) and primary open-angle glaucoma (POAG) have been
linked to decreased conventional outflow of aqueous humor (AH). To better understand the …
linked to decreased conventional outflow of aqueous humor (AH). To better understand the …
Pseudoexfoliation syndrome and glaucoma: from genes to disease mechanisms
PEX-associated genes are beginning to reveal relevant biological pathways and processes
involved in disease development. To understand the functional consequences and …
involved in disease development. To understand the functional consequences and …
Primary open angle glaucoma prevalence in Europe: a systematic review and meta-analysis
Purpose: This study aimed to evaluate the prevalence of POAG in Europe. Methods: Two
authors independently conducted a systematic literature search on PubMed/MedLine, Web …
authors independently conducted a systematic literature search on PubMed/MedLine, Web …